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J. Dev. Biol. 2016, 4(4), 30; doi:10.3390/jdb4040030

Hedgehog Signaling in Prostate Development, Regeneration and Cancer

Department of Urology, Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53705, USA
Academic Editors: Henk Roelink and Simon J. Conway
Received: 17 August 2016 / Revised: 27 September 2016 / Accepted: 4 October 2016 / Published: 19 October 2016
(This article belongs to the Special Issue Hedgehog Signaling in Embryogenesis)
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Abstract

The prostate is a developmental model system study of prostate growth regulation. Historically the research focus was on androgen regulation of development and growth and instructive interactions between the mesenchyme and epithelium. The study of Hh signaling in prostate development revealed important roles in ductal morphogenesis and in epithelial growth regulation that appear to be recapitulated in prostate cancer. This overview of Hh signaling in the prostate will address the well-described role of paracrine signaling prostate development as well as new evidence suggesting a role for autocrine signaling, the role of Hh signaling in prostate regeneration and reiterative activities in prostate cancer. View Full-Text
Keywords: Hedgehog; prostate; cancer Hedgehog; prostate; cancer
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Bushman, W. Hedgehog Signaling in Prostate Development, Regeneration and Cancer. J. Dev. Biol. 2016, 4, 30.

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