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J. Dev. Biol. 2016, 4(3), 28; doi:10.3390/jdb4030028

Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage

1
Neuroprotective, Neuroregenerative and Remyelinating Small Molecules’ U1195, INSERM—Université Paris-Sud, Université Paris-Saclay, 80 rue du Général Leclerc, Kremlin-Bicêtre F-94276, France
2
IRCM, Molecular Biology of Neural Development, 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Henk Roelink and Simon J. Conway
Received: 15 July 2016 / Revised: 26 August 2016 / Accepted: 31 August 2016 / Published: 8 September 2016
(This article belongs to the Special Issue Hedgehog Signaling in Embryogenesis)
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Abstract

The Hedgehog morphogen aroused an enormous interest since it was characterized as an essential signal for ventral patterning of the spinal cord two decades ago. The pathway is notably implicated in the initial appearance of the progenitors of oligodendrocytes (OPCs), the glial cells of the central nervous system which after maturation are responsible for axon myelination. In accordance with the requirement for Hedgehog signaling in ventral patterning, the earliest identifiable cells in the oligodendrocyte lineage are derived from the ventral ventricular zone of the developing spinal cord and brain. Here, we present the current knowledge about the involvement of Hedgehog signaling in the strict spatial and temporal regulation which characterizes the initiation and progression of the oligodendrocyte lineage. We notably describe the ability of the Hedgehog signaling to tightly orchestrate the appearance of specific combinations of genes in concert with other pathways. We document the molecular mechanisms controlling Hedgehog temporal activity during OPC specification. The contribution of the pathway to aspects of OPC development different from their specification is also highlighted especially in the optic nerve. Finally, we report the data demonstrating that Hedgehog signaling-dependency is not a universal situation for oligodendrocyte generation as evidenced in the dorsal spinal cord in contrast to the dorsal forebrain. View Full-Text
Keywords: oligodendrocyte; neural tube; forebrain; optic nerve; Smoothened; Patched; Gli oligodendrocyte; neural tube; forebrain; optic nerve; Smoothened; Patched; Gli
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MDPI and ACS Style

Traiffort, E.; Zakaria, M.; Laouarem, Y.; Ferent, J. Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage. J. Dev. Biol. 2016, 4, 28.

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J. Dev. Biol. EISSN 2221-3759 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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