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J. Dev. Biol. 2015, 3(4), 158-176; doi:10.3390/jdb3040158

Col11a1 Regulates Bone Microarchitecture during Embryonic Development

1
Biomolecular Research Center, Boise State University, 1910 University Drive, Boise, ID 83706-1511, USA
2
Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
3
College of Dental Medicine, Roseman University, South Jordan, UT 84095, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Andy Wessels
Received: 2 November 2015 / Revised: 4 December 2015 / Accepted: 9 December 2015 / Published: 16 December 2015
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Abstract

Collagen XI alpha 1 (Col11a1) is an extracellular matrix molecule required for embryonic development with a role in both nucleating the formation of fibrils and regulating the diameter of heterotypic fibrils during collagen fibrillar assembly. Although found in many different tissues throughout the vertebrate body, Col11a1 plays an essential role in endochondral ossification. To further understand the function of Col11a1 in the process of bone formation, we compared skeletal mineralization in wild-type (WT) mice and Col11a1-deficient mice using X-ray microtomography (micro-CT) and histology. Changes in trabecular bone microstructure were observed and are presented here. Additionally, changes to the periosteal bone collar of developing long bones were observed and resulted in an increase in thickness in the case of Col11a1-deficient mice compared to WT littermates. Vertebral bodies were incompletely formed in the absence of Col11a1. The data demonstrate that Col11a1 depletion results in alteration to newly-formed bone and is consistent with a role for Col11a1 in mineralization. These findings indicate that expression of Col11a1 in the growth plate and perichondrium is essential for trabecular bone and bone collar formation during endochondral ossification. The observed changes to mineralized tissues further define the function of Col11a1. View Full-Text
Keywords: Collagen XI; Col11a1; mineralization; chondrodysplasia; X-ray microtomography Collagen XI; Col11a1; mineralization; chondrodysplasia; X-ray microtomography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hafez, A.; Squires, R.; Pedracini, A.; Joshi, A.; Seegmiller, R.E.; Oxford, J.T. Col11a1 Regulates Bone Microarchitecture during Embryonic Development. J. Dev. Biol. 2015, 3, 158-176.

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J. Dev. Biol. EISSN 2221-3759 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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