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J. Dev. Biol. 2015, 3(1), 11-24; doi:10.3390/jdb3010011

Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation

Center for Cell Biology & Cancer Research, Albany Medical College, Albany, New York, NY 12208, USA
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Academic Editor: Robin Muise-Helmericks
Received: 13 January 2015 / Revised: 10 February 2015 / Accepted: 12 February 2015 / Published: 2 March 2015
(This article belongs to the Special Issue Wound Healing and Tissue Regeneration)
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Abstract

Plasminogen activator inhibitor-1 (PAI-1; SERPINE1) is a prominent member of the serine protease inhibitor superfamily (SERPIN) and a causative factor of multi-organ fibrosis as well as a key regulator of the tissue repair program. PAI-1 attenuates pericellular proteolysis by inhibiting the catalytic activity of both urokinase and tissue-type protease activators (uPA and tPA) effectively modulating, thereby, plasmin-mediated fibrinolysis and the overall pericellular proteolytic cascade. PAI-1 also impacts cellular responses to tissue injury and stress situations (growth, survival, migration) by titering the locale and temporal activation of multimeric cell-surface signaling complexes. This review will describe PAI-1 structure and function and detail the role of PAI-1 in the tissue repair program with an emphasis on cutaneous wound healing. View Full-Text
Keywords: SERPINE1; PAI-1; migration; proliferation; pericellular proteolysis; tiplaxtinin; fibrosis; TGF-β; wound healing; apoptosis SERPINE1; PAI-1; migration; proliferation; pericellular proteolysis; tiplaxtinin; fibrosis; TGF-β; wound healing; apoptosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Simone, T.M.; Higgins, P.J. Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation. J. Dev. Biol. 2015, 3, 11-24.

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