Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health
AbstractCathelicidins are a group of oral antimicrobial peptides that play multiple vital roles in the human body, such as their antimicrobial (broad spectrum) role against oral microbes, wound healing, and angiogenesis, with recent evidences about their role in cancer regulation. Cathelicidins are present in humans and other mammals as well. By complex interactions with the microenvironment, it results in pro-inflammatory effects. Many in vitro and in vivo experiments have been conducted to ultimately conclude that these unique peptides play an essential role in innate immunity. Peptides are released in the precursor form (defensins), which after cleavage results in cathelicidins formation. Living in the era where the major focus is on non-invasive and nanotechnology, this ultimately leads to further advancements in the field of salivaomics. Based on current spotlight innovations, we have highlighted the biochemistry, mode of action, and the importance of cathelicidins in the oral cavity. View Full-Text
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Khurshid, Z.; Naseem, M.; Yahya I. Asiri, F.; Mali, M.; Sannam Khan, R.; Sahibzada, H.A.; Zafar, M.S.; Faraz Moin, S.; Khan, E. Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health. Biomolecules 2017, 7, 80.
Khurshid Z, Naseem M, Yahya I. Asiri F, Mali M, Sannam Khan R, Sahibzada HA, Zafar MS, Faraz Moin S, Khan E. Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health. Biomolecules. 2017; 7(4):80.Chicago/Turabian Style
Khurshid, Zohaib; Naseem, Mustafa; Yahya I. Asiri, Faris; Mali, Maria; Sannam Khan, Rabia; Sahibzada, Haafsa A.; Zafar, Muhammad S.; Faraz Moin, Syed; Khan, Erum. 2017. "Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health." Biomolecules 7, no. 4: 80.
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