Next Article in Journal
The Physiological and Pathological Implications of the Formation of Hydrogels, with a Specific Focus on Amyloid Polypeptides
Previous Article in Journal
Structure-Dependent Interfacial Properties of Chaplin F from Streptomyces coelicolor
Article Menu

Export Article

Open AccessArticle
Biomolecules 2017, 7(3), 69; doi:10.3390/biom7030069

Self-Assembly of Human Serum Albumin: A Simplex Phenomenon

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G-1H9, Canada
Author to whom correspondence should be addressed.
Academic Editor: Jürg Bähler
Received: 15 August 2017 / Revised: 14 September 2017 / Accepted: 14 September 2017 / Published: 20 September 2017
View Full-Text   |   Download PDF [2765 KB, uploaded 21 September 2017]   |  


Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a n-simplex model and is explained through thermodynamics and chemical kinetics. View Full-Text
Keywords: protein self-assembly; Pascal’s triangle; n-simplex; geometric pattern; thermodynamics; kinetics protein self-assembly; Pascal’s triangle; n-simplex; geometric pattern; thermodynamics; kinetics

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Thakur, G.; Prashanthi, K.; Jiang, K.; Thundat, T. Self-Assembly of Human Serum Albumin: A Simplex Phenomenon. Biomolecules 2017, 7, 69.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top