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Biomolecules 2017, 7(3), 69; doi:10.3390/biom7030069

Self-Assembly of Human Serum Albumin: A Simplex Phenomenon

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G-1H9, Canada
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Academic Editor: Jürg Bähler
Received: 15 August 2017 / Revised: 14 September 2017 / Accepted: 14 September 2017 / Published: 20 September 2017
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Abstract

Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a n-simplex model and is explained through thermodynamics and chemical kinetics. View Full-Text
Keywords: protein self-assembly; Pascal’s triangle; n-simplex; geometric pattern; thermodynamics; kinetics protein self-assembly; Pascal’s triangle; n-simplex; geometric pattern; thermodynamics; kinetics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Thakur, G.; Prashanthi, K.; Jiang, K.; Thundat, T. Self-Assembly of Human Serum Albumin: A Simplex Phenomenon. Biomolecules 2017, 7, 69.

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