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Biomolecules 2017, 7(2), 40; doi:10.3390/biom7020040

Meristem Plant Cells as a Sustainable Source of Redox Actives for Skin Rejuvenation

1
Centre of Innovative Biotechnological Investigations “NANOLAB”, 197/2 Vernadsky Pr., Moscow 119571, Russia
2
Medena AG., Industriestrasse 16, CH-8910 Affoltern-am-Abis, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Michael Breitenbach
Received: 4 April 2017 / Revised: 3 May 2017 / Accepted: 8 May 2017 / Published: 12 May 2017
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Abstract

Recently, aggressive advertisement claimed a “magic role” for plant stem cells in human skin rejuvenation. This review aims to shed light on the scientific background suggesting feasibility of using plant cells as a basis of anti-age cosmetics. When meristem cell cultures obtained from medicinal plants are exposed to appropriate elicitors/stressors (ultraviolet, ultrasound ultraviolet (UV), ultrasonic waves, microbial/insect metabolites, heavy metals, organic toxins, nutrient deprivation, etc.), a protective/adaptive response initiates the biosynthesis of secondary metabolites. Highly bioavailable and biocompatible to human cells, low-molecular weight plant secondary metabolites share structural/functional similarities with human non-protein regulatory hormones, neurotransmitters, pigments, polyamines, amino-/fatty acids. Their redox-regulated biosynthesis triggers in turn plant cell antioxidant and detoxification molecular mechanisms resembling human cell pathways. Easily isolated in relatively large quantities from contaminant-free cell cultures, plant metabolites target skin ageing mechanisms, above all redox imbalance. Perfect modulators of cutaneous oxidative state via direct/indirect antioxidant action, free radical scavenging, UV protection, and transition-metal chelation, they are ideal candidates to restore photochemical/redox/immune/metabolic barriers, gradually deteriorating in the ageing skin. The industrial production of plant meristem cell metabolites is toxicologically and ecologically sustainable for fully “biological” anti-age cosmetics. View Full-Text
Keywords: cosmetics; environmental stress; meristem plant cells; plant metabolites; polyphenols; RNS; ROS; skin photoageing; skin rejuvenation; UV cosmetics; environmental stress; meristem plant cells; plant metabolites; polyphenols; RNS; ROS; skin photoageing; skin rejuvenation; UV
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Korkina, L.G.; Mayer, W.; de Luca, C. Meristem Plant Cells as a Sustainable Source of Redox Actives for Skin Rejuvenation. Biomolecules 2017, 7, 40.

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