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Biomolecules 2017, 7(1), 6; doi:10.3390/biom7010006

Critical Minireview: The Fate of tRNACys during Oxidative Stress in Bacillus subtilis

1
Facultad de Química, Universidad Autónoma de Querétaro, Cerro de las Campanas s/n, 76010 Querétaro, Qro., Mexico
2
Department of Biology, Emory University, Atlanta, GA 30322, USA
3
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Cerro de las Campanas s/n, 76010 Querétaro, Qro., Mexico
4
Centro de Investigación y de Estudios Avanzados del IPN, P.O. Box 629, 36500 Irapuato, GTO, Mexico
5
CONACYT, Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna Hermosillo No. 140, 25294 Saltillo, Coahuila, Mexico
6
Facultad de Medicina, Universidad Autónoma de Querétaro, Cerro de las Campanas s/n, 76010 Querétaro, Qro., Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Valérie de Crécy-Lagard
Received: 14 November 2016 / Revised: 12 January 2017 / Accepted: 13 January 2017 / Published: 20 January 2017
(This article belongs to the Special Issue tRNA Modifications: Synthesis, Function and Beyond)
View Full-Text   |   Download PDF [981 KB, uploaded 20 January 2017]   |  

Abstract

Oxidative stress occurs when cells are exposed to elevated levels of reactive oxygen species that can damage biological molecules. One bacterial response to oxidative stress involves disulfide bond formation either between protein thiols or between protein thiols and low-molecular-weight (LMW) thiols. Bacillithiol was recently identified as a major low-molecular-weight thiol in Bacillus subtilis and related Firmicutes. Four genes (bshA, bshB1, bshB2, and bshC) are involved in bacillithiol biosynthesis. The bshA and bshB1 genes are part of a seven-gene operon (ypjD), which includes the essential gene cca, encoding CCA-tRNA nucleotidyltransferase. The inclusion of cca in the operon containing bacillithiol biosynthetic genes suggests that the integrity of the 3′ terminus of tRNAs may also be important in oxidative stress. The addition of the 3′ terminal CCA sequence by CCA-tRNA nucleotidyltransferase to give rise to a mature tRNA and functional molecules ready for aminoacylation plays an essential role during translation and expression of the genetic code. Any defects in these processes, such as the accumulation of shorter and defective tRNAs under oxidative stress, might exert a deleterious effect on cells. This review summarizes the physiological link between tRNACys regulation and oxidative stress in Bacillus. View Full-Text
Keywords: bacillithiol; Bacillus; oxidative stress; tRNA bacillithiol; Bacillus; oxidative stress; tRNA
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MDPI and ACS Style

Campos Guillen, J.; Jones, G.H.; Saldaña Gutiérrez, C.; Hernández-Flores, J.L.; Cruz Medina, J.A.; Valenzuela Soto, J.H.; Pacheco Hernández, S.; Romero Gómez, S.; Morales Tlalpan, V. Critical Minireview: The Fate of tRNACys during Oxidative Stress in Bacillus subtilis. Biomolecules 2017, 7, 6.

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