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Biomolecules 2016, 6(4), 44; doi:10.3390/biom6040044

The Role of miRNAs in Common Inflammatory Arthropathies: Osteoarthritis and Gouty Arthritis

1
Department of Nursing, Faculty of Human Movement and Quality of Life Sciences, University of Peloponnese, Orthias Artemidos and Plateon St, GR-23100 Sparti, Greece
2
Immunology Laboratory, Immunology Department, Hellenic Pasteur Institute, P.O Box 115 21, Athens, Greece
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Jürg Bähler
Received: 8 August 2016 / Revised: 29 October 2016 / Accepted: 2 November 2016 / Published: 11 November 2016
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Abstract

MicroRNAs (miRNAs) are small, non-coding RNA species that are highly evolutionarily conserved, from higher invertebrates to man. Up to 1000 miRNAs have been identified in human cells thus far, where they are key regulators of the expression of numerous targets at the post-transcriptional level. They are implicated in various processes, including cell differentiation, metabolism, and inflammation. An expanding list of miRNAs is known to be involved in the pathogenesis of common, non-autoimmune inflammatory diseases. Interestingly, osteoarthritis (OA) is now being conceptualized as a metabolic disease, as there is a correlation among hyperuricemia and metabolic syndrome (MetS). Experimental evidence suggests that metabolic deregulation is a commonality between these different pathological entities, and that miRNAs are key players in the modulation of metabolic routes. In light of these findings, this review discusses the role of miRNAs in OA and gouty arthritis, as well as the possible therapeutic targetability of miRNAs in these diseases. View Full-Text
Keywords: arthropathy; post-transcriptional regulator; metaflammation; overweight; cartilage erosion; hyperuricemia; monosodium urate crystals arthropathy; post-transcriptional regulator; metaflammation; overweight; cartilage erosion; hyperuricemia; monosodium urate crystals
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Papanagnou, P.; Stivarou, T.; Tsironi, M. The Role of miRNAs in Common Inflammatory Arthropathies: Osteoarthritis and Gouty Arthritis. Biomolecules 2016, 6, 44.

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