Biomolecules 2015, 5(4), 2363-2387; doi:10.3390/biom5042363
RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
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Academic Editor: André P. Gerber
Received: 28 May 2015 / Revised: 16 September 2015 / Accepted: 23 September 2015 / Published: 30 September 2015
(This article belongs to the Special Issue RNA-Binding Proteins—Structure, Function, Networks and Disease)
Abstract
Posttranscriptional modifications of messenger RNAs (mRNAs) are key processes in the fine-tuning of cellular homeostasis. Two major actors in this scenario are RNA binding proteins (RBPs) and microRNAs (miRNAs) that together play important roles in the biogenesis, turnover, translation and localization of mRNAs. This review will highlight recent advances in the understanding of the role of RBPs in the regulation of the maturation and the function of miRNAs. The interplay between miRNAs and RBPs is discussed specifically in the context of neuronal development and function. View Full-TextKeywords:
miRNA; RNA binding proteins; RBPs; neuronal-gene-expression-regulation; miRNA-RBP cooperation; miRNA-RBP competition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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MDPI and ACS Style
Loffreda, A.; Rigamonti, A.; Barabino, S.M.L.; Lenzken, S.C. RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions. Biomolecules 2015, 5, 2363-2387.
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