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Biomolecules 2015, 5(2), 343-355; doi:10.3390/biom5020343

Function and Pathological Implications of Exon Junction Complex Factor Y14

Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: André P. Gerber
Received: 26 February 2015 / Revised: 31 March 2015 / Accepted: 1 April 2015 / Published: 10 April 2015
(This article belongs to the Special Issue RNA-Binding Proteins—Structure, Function, Networks and Disease)
View Full-Text   |   Download PDF [158 KB, uploaded 10 April 2015]

Abstract

Eukaryotic mRNA biogenesis involves a series of interconnected steps, including nuclear pre-mRNA processing, mRNA export, and surveillance. The exon-junction complex (EJC) is deposited on newly spliced mRNAs and coordinates several downstream steps of mRNA biogenesis. The EJC core protein, Y14, functions with its partners in nonsense-mediated mRNA decay and translational enhancement. Y14 plays additional roles in mRNA metabolism, some of which are independent of the EJC, and it is also involved in other cellular processes. Genetic mutations or aberrant expression of Y14 results in physiological abnormality and may cause disease. Therefore, it is important to understand the various functions of Y14 and its physiological and pathological roles. View Full-Text
Keywords: exon-junction complex; nonsense-mediated mRNA decay; translation; pre-mRNA splicing; centrosome exon-junction complex; nonsense-mediated mRNA decay; translation; pre-mRNA splicing; centrosome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chuang, T.-W.; Lee, K.-M.; Tarn, W.-Y. Function and Pathological Implications of Exon Junction Complex Factor Y14. Biomolecules 2015, 5, 343-355.

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