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Biomolecules 2015, 5(1), 263-281; doi:10.3390/biom5010263

Growth Factor Dependent Regulation of Centrosome Function and Genomic Instability by HuR

Department of Neurology, University of Alabama at Birmingham, 510 20th Street South, FOT 1020, Birmingham, AL 35209, USA
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Author to whom correspondence should be addressed.
Academic Editor: André P. Gerber
Received: 22 December 2014 / Revised: 6 March 2015 / Accepted: 11 March 2015 / Published: 20 March 2015
(This article belongs to the Special Issue RNA-Binding Proteins—Structure, Function, Networks and Disease)
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Abstract

The mRNA binding protein HuR is over expressed in cancer cells and contributes to disease progression through post-transcriptional regulation of mRNA. The regulation of HuR and how this relates to glioma is the focus of this report. SRC and c-Abl kinases regulate HuR sub-cellular trafficking and influence accumulation in the pericentriolar matrix (PCM) via a growth factor dependent signaling mechanism. Growth factor stimulation of glioma cell lines results in the associate of HuR with the PCM and amplification of centrosome number. This process is regulated by tyrosine phosphorylation of HuR and is abolished by mutating tyrosine residues. HuR is overexpressed in tumor samples from patients with glioblastoma and associated with a reduced survival. These findings suggest HuR plays a significant role in centrosome amplification and genomic instability, which contributes to a worse disease outcome. View Full-Text
Keywords: ABL tyrosine kinase; cell signaling; centrosome; genomic instability; RNA binding protein; Src ABL tyrosine kinase; cell signaling; centrosome; genomic instability; RNA binding protein; Src
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Filippova, N.; Yang, X.; Nabors, L.B. Growth Factor Dependent Regulation of Centrosome Function and Genomic Instability by HuR. Biomolecules 2015, 5, 263-281.

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