biomolecules Biomolecules Biomolecules Biomolecules 2218-273X MDPI 10.3390/biom3010072 biomolecules-03-00072 Correction Correction: Kousholt, A.N. et al. Pathways for Genome Integrity in G2 Phase of the Cell Cycle. Biomolecules 2012, 2, 579-607 Kousholt Arne Nedergaard † Menzel Tobias † Sørensen Claus Storgaard * Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark, E-Mails: ank@bric.ku.dk (A.N.K.); TME@bric.ku.dk (T.M.)

These authors contributed equally to this work.

 Author to whom correspondence should be addressed; E-Mail: css@bric.ku.dk; Tel.: +45 3532 5678; Fax: +45 3532 5669. 15 01 2013 03 2013 3 1 72 74 11 01 2013 © 2013 by the authors; licensee MDPI, Basel, Switzerland. 2013

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

We have discovered an error in our paper published in Biomolecules [1], in Figure 1 on page 589. The protein names ATR and ATRIP have been swapped. A corrected version of the Figure 1 is provided below.

Activation of the checkpoint regulator (CHK1) in response to DNA Double Strand Breaks (DSBs). The MRN complex detects DSBs and recruits Ataxia Telangiectasia Mutated (ATM) to initiate checkpoint signaling. During the S and G2 phases of the cell cycle, dsDNA resection can be performed by the nucleases DNA2 and EXO1, together with CtIP. The resulting ssDNA is coated by RPA, and is prepared for HR repair. Furthermore, ssDNA-coated by RPA recruits the ATR/ ATR interacting protein (ATRIP) complex as well as TopBP1 via the 9-1-1 complex, enabling full ATR activity. ATR then activates a subset of targets, including CHK1. CHK1 can phosphorylate CDC25A in response to DSBs, targeting CDC25A for proteasomal degradation. Since CDC25A is required for CDK1 activity to facilitate mitotic entry, cells arrest in the G2 phase upon CDC25A degradation.

 References Kousholt A.N. Menzel T. Sørensen C.S. Pathways for Genome Integrity in G2 Phase of the Cell Cycle Biomolecules 2012 2 579 607 10.3390/biom2040579