Biomolecules 2012, 2(2), 288-311; doi:10.3390/biom2020288

Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants

1,* email and 2email
Received: 7 May 2012; in revised form: 13 June 2012 / Accepted: 13 June 2012 / Published: 22 June 2012
(This article belongs to the Special Issue Feature Papers)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: LRRs (leucine rich repeats) are present in over 14,000 proteins. Non-LRR, island regions (IRs) interrupting LRRs are widely distributed. The present article reviews 19 families of LRR proteins having non-LRR IRs (LRR@IR proteins) from various plant species. The LRR@IR proteins are LRR-containing receptor-like kinases (LRR-RLKs), LRR-containing receptor-like proteins (LRR-RLPs), TONSOKU/BRUSHY1, and MJK13.7; the LRR-RLKs are homologs of TMK1/Rhg4, BRI1, PSKR, PSYR1, Arabidopsis At1g74360, and RPK2, while the LRR-RLPs are those of Cf-9/Cf-4, Cf-2/Cf-5, Ve, HcrVf, RPP27, EIX1, clavata 2, fascinated ear2, RLP2, rice Os10g0479700, and putative soybean disease resistance protein. The LRRs are intersected by single, non-LRR IRs; only the RPK2 homologs have two IRs. In most of the LRR-RLKs and LRR-RLPs, the number of repeat units in the preceding LRR block (N1) is greater than the number of the following block (N2); N1 » N2 in which N1 is variable in the homologs of individual families, while N2 is highly conserved. The five families of the LRR-RLKs except for the RPK2 family show N1 = 8 − 18 and N2 = 3 − 5. The nine families of the LRR-RLPs show N1 = 12 − 33 and N2 = 4; while N1 = 6 and N2 = 4 for the rice Os10g0479700 family and the N1 = 4 − 28 and N2 = 4 for the soybean protein family. The rule of N1 » N2 might play a common, significant role in ligand interaction, dimerization, and/or signal transduction of the LRR-RLKs and the LRR-RLPs. The structure and evolution of the LRR domains with non-LRR IRs and their proteins are also discussed.
Keywords: leucine-rich repeats; Non-LRR island; LRR-RLK; LRR-RLP; TMK1; Os10g0479700; TONSOKU/BRUSHY1; MJK13.7; ligand interaction; dimerization
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MDPI and ACS Style

Matsushima, N.; Miyashita, H. Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants. Biomolecules 2012, 2, 288-311.

AMA Style

Matsushima N, Miyashita H. Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants. Biomolecules. 2012; 2(2):288-311.

Chicago/Turabian Style

Matsushima, Norio; Miyashita, Hiroki. 2012. "Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants." Biomolecules 2, no. 2: 288-311.

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