Next Article in Journal
A Topological Characterization of Medium-Dependent Essential Metabolic Reactions
Next Article in Special Issue
Differentiating Hepatocellular Carcinoma from Hepatitis C Using Metabolite Profiling
Previous Article in Journal
Metabolic and Pharmacokinetic Differentiation of STX209 and Racemic Baclofen in Humans
Previous Article in Special Issue
Minimal Cut Sets and the Use of Failure Modes in Metabolic Networks
Metabolites 2012, 2(3), 614-631; doi:10.3390/metabo2030614

What mRNA Abundances Can Tell us about Metabolism

Institute for Biochemistry, Charité University Medicine Berlin, Charitéplatz 1, Berlin 10117, Germany
Received: 1 August 2012 / Revised: 24 August 2012 / Accepted: 4 September 2012 / Published: 12 September 2012
(This article belongs to the Special Issue Metabolism and Systems Biology)
View Full-Text   |   Download PDF [165 KB, uploaded 12 September 2012]


Inferring decreased or increased metabolic functions from transcript profiles is at first sight a bold and speculative attempt because of the functional layers in between: proteins, enzymatic activities, and reaction fluxes. However, the growing interest in this field can easily be explained by two facts: the high quality of genome-scale metabolic network reconstructions and the highly developed technology to obtain genome-covering RNA profiles. Here, an overview of important algorithmic approaches is given by means of criteria by which published procedures can be classified. The frontiers of the methods are sketched and critical voices are being heard. Finally, an outlook for the prospects of the field is given.
Keywords: transcriptomics; metabolic network; metabolism; metabolic function; Virtual-Liver Network transcriptomics; metabolic network; metabolism; metabolic function; Virtual-Liver Network
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Hoppe, A. What mRNA Abundances Can Tell us about Metabolism. Metabolites 2012, 2, 614-631.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Metabolites EISSN 2218-1989 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert