Metabolites 2012, 2(3), 614-631; doi:10.3390/metabo2030614

What mRNA Abundances Can Tell us about Metabolism

Received: 1 August 2012; in revised form: 24 August 2012 / Accepted: 4 September 2012 / Published: 12 September 2012
(This article belongs to the Special Issue Metabolism and Systems Biology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Inferring decreased or increased metabolic functions from transcript profiles is at first sight a bold and speculative attempt because of the functional layers in between: proteins, enzymatic activities, and reaction fluxes. However, the growing interest in this field can easily be explained by two facts: the high quality of genome-scale metabolic network reconstructions and the highly developed technology to obtain genome-covering RNA profiles. Here, an overview of important algorithmic approaches is given by means of criteria by which published procedures can be classified. The frontiers of the methods are sketched and critical voices are being heard. Finally, an outlook for the prospects of the field is given.
Keywords: transcriptomics; metabolic network; metabolism; metabolic function; Virtual-Liver Network
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MDPI and ACS Style

Hoppe, A. What mRNA Abundances Can Tell us about Metabolism. Metabolites 2012, 2, 614-631.

AMA Style

Hoppe A. What mRNA Abundances Can Tell us about Metabolism. Metabolites. 2012; 2(3):614-631.

Chicago/Turabian Style

Hoppe, Andreas. 2012. "What mRNA Abundances Can Tell us about Metabolism." Metabolites 2, no. 3: 614-631.

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