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Metabolites 2012, 2(1), 214-220; doi:10.3390/metabo2010214
Article

Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species

1, 2, 3, 4, 5, 6 and 5,*
1 Department of Forensic Medicine, University of Copenhagen, Frederik V’s Vej 11, DK-2100 Copenhagen, Denmark 2 Carlsberg Laboratory, Gamle Carlsbergvej 10, DK-2500 Valby, Denmark 3 Munkehøjvænge 31, 3520 Farum, Denmark 4 Institut für Pharmazie, Leopold-Franzens-Universität, Innrain 52, A-6020 Innsbruck, Austria 5 Center for Microbial Biotechnology, DTU Systems Biology, Building 221, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark 6 Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark
* Author to whom correspondence should be addressed.
Received: 7 November 2011 / Revised: 30 December 2011 / Accepted: 10 February 2012 / Published: 23 February 2012
(This article belongs to the Special Issue Secondary Metabolites and Metabolism)
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Abstract

Atlantinone A has been isolated from the psychrotolerant fungus Penicillium ribeum. The exact structure of the compound was confirmed by mass spectrometric and 1- and 2D NMR experiments. Atlantinone A was originally only produced upon chemical epigenetic manipulation of P. hirayamae, however in this study the compound was found to be produced at standard growth conditions by the following species; P. solitum, P. discolor, P. commune, P. caseifulvum, P. palitans, P. novae-zeelandiae and P. monticola. A biosynthetic pathway to atlantinone A starting from andrastin A is proposed.
Keywords: Penicillium ribeum; atlantinone A; andrastin; psychrotolerant; cheese associated fungi Penicillium ribeum; atlantinone A; andrastin; psychrotolerant; cheese associated fungi
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Dalsgaard, P.W.; Petersen, B.O.; Duus, J.Ø.; Zidorn, C.; Frisvad, J.C.; Christophersen, C.; Larsen, T.O. Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species. Metabolites 2012, 2, 214-220.

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