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Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species
Department of Forensic Medicine, University of Copenhagen, Frederik V’s Vej 11, DK-2100 Copenhagen, Denmark
Carlsberg Laboratory, Gamle Carlsbergvej 10, DK-2500 Valby, Denmark
Munkehøjvænge 31, 3520 Farum, Denmark
Institut für Pharmazie, Leopold-Franzens-Universität, Innrain 52, A-6020 Innsbruck, Austria
Center for Microbial Biotechnology, DTU Systems Biology, Building 221, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark
Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark
* Author to whom correspondence should be addressed.
Received: 7 November 2011; in revised form: 30 December 2011 / Accepted: 10 February 2012 / Published: 23 February 2012
Abstract: Atlantinone A has been isolated from the psychrotolerant fungus Penicillium ribeum. The exact structure of the compound was confirmed by mass spectrometric and 1- and 2D NMR experiments. Atlantinone A was originally only produced upon chemical epigenetic manipulation of P. hirayamae, however in this study the compound was found to be produced at standard growth conditions by the following species; P. solitum, P. discolor, P. commune, P. caseifulvum, P. palitans, P. novae-zeelandiae and P. monticola. A biosynthetic pathway to atlantinone A starting from andrastin A is proposed.
Keywords: Penicillium ribeum; atlantinone A; andrastin; psychrotolerant; cheese associated fungi
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Dalsgaard, P.W.; Petersen, B.O.; Duus, J.Ø.; Zidorn, C.; Frisvad, J.C.; Christophersen, C.; Larsen, T.O. Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species. Metabolites 2012, 2, 214-220.
Dalsgaard PW, Petersen BO, Duus JØ, Zidorn C, Frisvad JC, Christophersen C, Larsen TO. Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species. Metabolites. 2012; 2(1):214-220.
Dalsgaard, Petur W.; Petersen, Bent O.; Duus, Jens Ø.; Zidorn, Christian; Frisvad, Jens C.; Christophersen, Carsten; Larsen, Thomas O. 2012. "Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species." Metabolites 2, no. 1: 214-220.