Next Article in Journal
Canonical Modeling of the Multi-Scale Regulation of the Heat Stress Response in Yeast
Next Article in Special Issue
A Historical Overview of Natural Products in Drug Discovery
Previous Article in Journal
Shotgun Lipidomics by Sequential Precursor Ion Fragmentation on a Hybrid Quadrupole Time-of-Flight Mass Spectrometer
Previous Article in Special Issue
Intracellular Metabolite Pool Changes in Response to Nutrient Depletion Induced Metabolic Switching in Streptomyces coelicolor
Article Menu

Export Article

Open AccessArticle
Metabolites 2012, 2(1), 214-220; doi:10.3390/metabo2010214

Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species

1
Department of Forensic Medicine, University of Copenhagen, Frederik V’s Vej 11, DK-2100 Copenhagen, Denmark
2
Carlsberg Laboratory, Gamle Carlsbergvej 10, DK-2500 Valby, Denmark
3
Munkehøjvænge 31, 3520 Farum, Denmark
4
Institut für Pharmazie, Leopold-Franzens-Universität, Innrain 52, A-6020 Innsbruck, Austria
5
Center for Microbial Biotechnology, DTU Systems Biology, Building 221, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark
6
Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
Received: 7 November 2011 / Revised: 30 December 2011 / Accepted: 10 February 2012 / Published: 23 February 2012
(This article belongs to the Special Issue Secondary Metabolites and Metabolism)
View Full-Text   |   Download PDF [415 KB, uploaded 23 February 2012]   |  

Abstract

Atlantinone A has been isolated from the psychrotolerant fungus Penicillium ribeum. The exact structure of the compound was confirmed by mass spectrometric and 1- and 2D NMR experiments. Atlantinone A was originally only produced upon chemical epigenetic manipulation of P. hirayamae, however in this study the compound was found to be produced at standard growth conditions by the following species; P. solitum, P. discolor, P. commune, P. caseifulvum, P. palitans, P. novae-zeelandiae and P. monticola. A biosynthetic pathway to atlantinone A starting from andrastin A is proposed.
Keywords: Penicillium ribeum; atlantinone A; andrastin; psychrotolerant; cheese associated fungi Penicillium ribeum; atlantinone A; andrastin; psychrotolerant; cheese associated fungi
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Dalsgaard, P.W.; Petersen, B.O.; Duus, J.Ø.; Zidorn, C.; Frisvad, J.C.; Christophersen, C.; Larsen, T.O. Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species. Metabolites 2012, 2, 214-220.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Metabolites EISSN 2218-1989 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top