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Metabolites 2012, 2(1), 214-220; doi:10.3390/metabo2010214
Article

Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species

1, 2, 3, 4, 5, 6 and 5,*
1 Department of Forensic Medicine, University of Copenhagen, Frederik V’s Vej 11, DK-2100 Copenhagen, Denmark 2 Carlsberg Laboratory, Gamle Carlsbergvej 10, DK-2500 Valby, Denmark 3 Munkehøjvænge 31, 3520 Farum, Denmark 4 Institut für Pharmazie, Leopold-Franzens-Universität, Innrain 52, A-6020 Innsbruck, Austria 5 Center for Microbial Biotechnology, DTU Systems Biology, Building 221, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark 6 Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark
* Author to whom correspondence should be addressed.
Received: 7 November 2011 / Revised: 30 December 2011 / Accepted: 10 February 2012 / Published: 23 February 2012
(This article belongs to the Special Issue Secondary Metabolites and Metabolism)
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Abstract

Atlantinone A has been isolated from the psychrotolerant fungus Penicillium ribeum. The exact structure of the compound was confirmed by mass spectrometric and 1- and 2D NMR experiments. Atlantinone A was originally only produced upon chemical epigenetic manipulation of P. hirayamae, however in this study the compound was found to be produced at standard growth conditions by the following species; P. solitum, P. discolor, P. commune, P. caseifulvum, P. palitans, P. novae-zeelandiae and P. monticola. A biosynthetic pathway to atlantinone A starting from andrastin A is proposed.
Keywords: Penicillium ribeum; atlantinone A; andrastin; psychrotolerant; cheese associated fungi Penicillium ribeum; atlantinone A; andrastin; psychrotolerant; cheese associated fungi
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Dalsgaard, P.W.; Petersen, B.O.; Duus, J.Ø.; Zidorn, C.; Frisvad, J.C.; Christophersen, C.; Larsen, T.O. Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species. Metabolites 2012, 2, 214-220.

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