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Metabolites 2012, 2(1), 214-220; doi:10.3390/metabo2010214
Article

Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species

1, 2, 3, 4, 5, 6 and 5,*
Received: 7 November 2011 / Revised: 30 December 2011 / Accepted: 10 February 2012 / Published: 23 February 2012
(This article belongs to the Special Issue Secondary Metabolites and Metabolism)
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Abstract

Atlantinone A has been isolated from the psychrotolerant fungus Penicillium ribeum. The exact structure of the compound was confirmed by mass spectrometric and 1- and 2D NMR experiments. Atlantinone A was originally only produced upon chemical epigenetic manipulation of P. hirayamae, however in this study the compound was found to be produced at standard growth conditions by the following species; P. solitum, P. discolor, P. commune, P. caseifulvum, P. palitans, P. novae-zeelandiae and P. monticola. A biosynthetic pathway to atlantinone A starting from andrastin A is proposed.
Keywords: Penicillium ribeum; atlantinone A; andrastin; psychrotolerant; cheese associated fungi Penicillium ribeum; atlantinone A; andrastin; psychrotolerant; cheese associated fungi
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dalsgaard, P.W.; Petersen, B.O.; Duus, J.Ø.; Zidorn, C.; Frisvad, J.C.; Christophersen, C.; Larsen, T.O. Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species. Metabolites 2012, 2, 214-220.

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