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Sci. Pharm. 2017, 85(1), 11; doi:10.3390/scipharm85010011

Alginate-Based Composite Sponges as Gastroretentive Carriers for Curcumin-Loaded Self-Microemulsifying Drug Delivery Systems

1
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand
2
Phytomedicine and Pharmaceutical Biotechnology Excellence Research Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand
3
Drug and Cosmetic Research and Development Unit, School of Pharmacy, Walailak University, Nakhon Si Thammarat 80161, Thailand
*
Author to whom correspondence should be addressed.
Academic Editor: Gernot Eller
Received: 19 December 2016 / Revised: 8 March 2017 / Accepted: 8 March 2017 / Published: 15 March 2017
View Full-Text   |   Download PDF [1999 KB, uploaded 15 March 2017]   |  

Abstract

Alginate-based composite sponges were developed as carriers to prolong the gastric retention time and controlled release of curcumin-loaded self-microemulsifying drug delivery systems (Cur-SMEDDS). Liquid Cur-SMEDDS was incorporated into a solution made up of a mixture of polymers and converted into a solid form by freeze-drying. The ratio of alginate as the main polymer, adsorbent (colloidal silicon dioxide), and additional polymers—sodium carboxymethyl cellulose (SCMC), hydroxypropyl methylcellulose (HPMC)—was varied systematically to adjust the drug loading and entrapment efficiency, sponge buoyancy, and the release profile of Cur-SMEDDS. The optimum composite sponge was fabricated from a 4% alginate and 2% HPMC mixed solution. It immediately floated on simulated gastric fluid (SGF, pH 1.2) and remained buoyant over an 8 h period. The formulation exhibited an emulsion droplet size of approximately 30 nm and provided sustained release of Cur-SMEDDS in SGF, reaching 71% within 8 h compared with only 10% release from curcumin powder. This study demonstrates the potential of alginate-based composite sponges combined with self-microemulsifying formulations for gastroretention applications involving poorly soluble compounds. View Full-Text
Keywords: curcumin; self-microemulsifying drug delivery systems; sponge; alginate curcumin; self-microemulsifying drug delivery systems; sponge; alginate
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Petchsomrit, A.; Sermkaew, N.; Wiwattanapatapee, R. Alginate-Based Composite Sponges as Gastroretentive Carriers for Curcumin-Loaded Self-Microemulsifying Drug Delivery Systems. Sci. Pharm. 2017, 85, 11.

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