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Sci. Pharm. 2016, 84(4), 685-693; doi:10.3390/scipharm84040685

Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes

1
Pharmaceutics Research Group, School of Pharmacy, Bandung Institute of Technology, Bandung 40132, Indonesia
2
Research Center for Nanosciences and Nanotechnology, Bandung Institute of Technology, Bandung 40132, Indonesia
3
Department of Pharmacy, Pharmaceutical Technology, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Berlin 12169, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Franz Gabor
Received: 11 August 2016 / Accepted: 31 August 2016 / Published: 18 October 2016
View Full-Text   |   Download PDF [2009 KB, uploaded 18 October 2016]   |  

Abstract

We have successfully developed curcumin nanosuspension intended for oral delivery. The main purpose is to improve bioavailability through enhancing its solubility. The nanoparticles were stabilized using various stabilizers, including polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), sodium carboxymethylcellulose (Na-CMC), d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), and sodium dodecyl sulfate (SDS). The average diameter of particles, microscopic appearance, and sedimentation of each preparation was observed and compared. Each stabilizer demonstrated a different degree of inhibition of particle aggregation under electrolyte-containing simulated gastrointestinal (GIT) fluid. Non-ionic stabilizers (PVA, PVP, and TPGS) were shown to preserve the nanosuspension stability against electrolytes. In contrast, strong ionic surfactants such as SDS were found to be very sensitive to electrolytes. The results can provide useful information for the formulators to choose the most suitable stabilizers by considering the nature of stabilizers and physiological characteristics of the target site of the drug. View Full-Text
Keywords: curcumin; nanosuspension; electrolyte; particle aggregation; stabilizer; ionic surfactant curcumin; nanosuspension; electrolyte; particle aggregation; stabilizer; ionic surfactant
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rachmawati, H.; Rahma, A.; Al Shaal, L.; Müller, R.H.; Keck, C.M. Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes. Sci. Pharm. 2016, 84, 685-693.

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