Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015).
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Sci. Pharm. 2016, 84(2), 269-278; doi:10.3797/scipharm.1507-08 (registering DOI)
Synthesis and Characterization of Compounds Related to Lisinopril
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No:71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Telangana, 502329, India
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, 500085, India
Affliated supervisor, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, 500085, India
Author to whom correspondence should be addressed.
Received: 9 July 2015 / Accepted: 18 October 2015 / Published: 18 October 2015
Abstract Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in the treatment of hypertension. During the scale-up of the lisinopril process, one unknown impurity was observed and is identified. The present work describes the origin, synthesis, characterization, and control of this impurity. This paper also describes the synthesis and characterization of three other impurities listed in the European Pharmacopoeia 8.4 (Impurity C, D, and F).
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RAGHAVA REDDY, A.V.; GARAGA, S.; TAKSHINAMOORTHY, C.; NAIDU, A.; DANDALA, R. Synthesis and Characterization of Compounds Related to Lisinopril. Sci. Pharm. 2016, 84, 269-278.
RAGHAVA REDDY AV, GARAGA S, TAKSHINAMOORTHY C, NAIDU A, DANDALA R. Synthesis and Characterization of Compounds Related to Lisinopril. Scientia Pharmaceutica. 2016; 84(2):269-278.
RAGHAVA REDDY, Ambati V.; GARAGA, Srinivas; TAKSHINAMOORTHY, Chandiran; NAIDU, Andra; DANDALA, Ramesh. 2016. "Synthesis and Characterization of Compounds Related to Lisinopril." Sci. Pharm. 84, no. 2: 269-278.
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