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Sci. Pharm. 2016, 84(2), 269-278; doi:10.3797/scipharm.1507-08

Synthesis and Characterization of Compounds Related to Lisinopril

1
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No:71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Telangana, 502329, India
2
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, 500085, India
3
Affliated supervisor, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, 500085, India
*
Author to whom correspondence should be addressed.
Received: 9 July 2015 / Accepted: 18 October 2015 / Published: 18 October 2015
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Abstract

Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in the treatment of hypertension. During the scale-up of the lisinopril process, one unknown impurity was observed and is identified. The present work describes the origin, synthesis, characterization, and control of this impurity. This paper also describes the synthesis and characterization of three other impurities listed in the European Pharmacopoeia 8.4 (Impurity C, D, and F).
Keywords: Lisinopril; Related substances; Origin; Synthesis; Characterization; Impurities Lisinopril; Related substances; Origin; Synthesis; Characterization; Impurities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

RAGHAVA REDDY, A.V.; GARAGA, S.; TAKSHINAMOORTHY, C.; NAIDU, A.; DANDALA, R. Synthesis and Characterization of Compounds Related to Lisinopril. Sci. Pharm. 2016, 84, 269-278.

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