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Sci. Pharm. 2016, 84(2), 255-268; doi:10.3797/scipharm.1505-16

Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones

Institute of Pharmacology and Toxicology, Eugene Pottier 14, 03057 Kiev, Ukraine
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Received: 20 May 2015 / Accepted: 27 August 2015 / Published: 27 August 2015
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Abstract

A series of novel 2-(N-pyrrolidino, N-piperidino or N-morpholino)-7-phenyl(α-furoyl or α-thienyl)-[1,3]thiazolo[4,5-d]pyridazinones 10a-c, 14-16a,b was synthesized in 78-87% yields via the reaction of methyl 5-benzoyl(α-furoyl or α-thienyl)-2-aminosubstituted-thiazol-4-carboxylates 9a-c, 13a-e with hydrazine. These new compounds have been tested for their in vivo analgesic and anti-inflammatory activities. All compounds have been characterized by 1H-NMR, 13C-NMR spectroscopy, and liquid chromatography-mass spectrometry.
Keywords: [1,3]Thiazolo[4,5-d]pyridazinones; Anti-inflammatory activity; Anаlgеsic activity; In vivo tests;«Hot plate» model; «Acetic acid cramps» model [1,3]Thiazolo[4,5-d]pyridazinones; Anti-inflammatory activity; Anаlgеsic activity; In vivo tests;«Hot plate» model; «Acetic acid cramps» model
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

DEMCHENKO, A.; BOBKOVA, L.; YADLOVSKIY, O.; BUCHTIAROVA, T.; DEMCHENKO, S. Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones. Sci. Pharm. 2016, 84, 255-268.

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