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Sci. Pharm. 2015, 83(3), 429-443; doi:10.3797/scipharm.1503-10

Synthesis and In Vitro Biological Evaluation of 1,3,4-Oxadiazol-2(3H)-one and Tetrahydropyridazine-3,6-dione Derivatives of Fatty Acids

1
Department of Chemistry, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India
2
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202 002, India
*
Author to whom correspondence should be addressed.
Received: 22 March 2015 / Accepted: 9 June 2015 / Published: 9 June 2015
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Abstract

Herein we report saturated and unsaturated fatty acid derivatives of 1,3,4-oxadiazol-2(3H)-one and tetrahydropyridazine-3,6-dione as new potential anticancer agents. All the synthesised compounds were characterised by IR, 1H-NMR, 13C-NMR, and mass spectral data. The relative sensitivity of three cancer cell lines varied depending on the nature of the compound. Among the most effective anticancer compounds studied, 3b and 6b displayed remarkable anticancer activity against the MDA-MB-231 and KCL-22 lines, respectively. On the other hand, compound 3c was found to be most sensitive to nearly all the tested cell lines, MDA-MB-231, KCL-22, and HeLa.
Keywords: 1,3,4-Oxadiazol-2-one; Tetrahydropyridazine-3,6-dione; Fatty acids; Cytotoxicity; SAR 1,3,4-Oxadiazol-2-one; Tetrahydropyridazine-3,6-dione; Fatty acids; Cytotoxicity; SAR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

HASSAN, M.F.; RAUF, A.; SHERWANI, A.; OWAIS, M. Synthesis and In Vitro Biological Evaluation of 1,3,4-Oxadiazol-2(3H)-one and Tetrahydropyridazine-3,6-dione Derivatives of Fatty Acids. Sci. Pharm. 2015, 83, 429-443.

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