Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015).
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Sci. Pharm. 2015, 83(3), 413-427; https://doi.org/10.3797/scipharm.1505-06 (registering DOI)
Improved Automated Radiosynthesis of [11C]PBR28
Department of Radiology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Author to whom correspondence should be addressed.
Received: 7 May 2015 / Accepted: 19 June 2015 / Published: 19 June 2015
Abstract Microglial activation is commonly identified by elevated levels of the 18 kDa translocator protein (TSPO) in response to several inflammatory processes. [11C]PBR28 is one of the most promising PET tracers to image TSPO in both human and non-human primates. In this study, we optimized the radiolabeling procedure of [11C]PBR28 for higher radiochemical yield, radiochemical purity, and specific activity, which can be easily translated to any automated module for clinical trials. Time-activity curves (TACs) derived from the dynamic PET imaging of male rhesus monkey brains demonstrated that [11C]PBR28 had suitable kinetics with radiotracer accumulation observed in the caudate, putamen, cerebellum, and frontal cortex region.
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SOLINGAPURAM SAI, K.K.; GAGE, D.; NADER, M.; MACH, R.H.; MINTZ, A. Improved Automated Radiosynthesis of [11C]PBR28. Sci. Pharm. 2015, 83, 413-427.
SOLINGAPURAM SAI KK, GAGE D, NADER M, MACH RH, MINTZ A. Improved Automated Radiosynthesis of [11C]PBR28. Scientia Pharmaceutica. 2015; 83(3):413-427.
SOLINGAPURAM SAI, Kiran Kumar; GAGE, Don; NADER, Mike; MACH, Robert H.; MINTZ, Akiva. 2015. "Improved Automated Radiosynthesis of [11C]PBR28." Sci. Pharm. 83, no. 3: 413-427.
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