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Sci. Pharm. 2015, 83(3), 413-427; doi:10.3797/scipharm.1505-06

Improved Automated Radiosynthesis of [11C]PBR28

1
Department of Radiology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA
2
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA
3
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
*
Author to whom correspondence should be addressed.
Received: 7 May 2015 / Accepted: 19 June 2015 / Published: 19 June 2015
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Abstract

Microglial activation is commonly identified by elevated levels of the 18 kDa translocator protein (TSPO) in response to several inflammatory processes. [11C]PBR28 is one of the most promising PET tracers to image TSPO in both human and non-human primates. In this study, we optimized the radiolabeling procedure of [11C]PBR28 for higher radiochemical yield, radiochemical purity, and specific activity, which can be easily translated to any automated module for clinical trials. Time-activity curves (TACs) derived from the dynamic PET imaging of male rhesus monkey brains demonstrated that [11C]PBR28 had suitable kinetics with radiotracer accumulation observed in the caudate, putamen, cerebellum, and frontal cortex region.
Keywords: Positron Emission Tomography (PET); Microglial activation; Synthesis; TSPO Positron Emission Tomography (PET); Microglial activation; Synthesis; TSPO
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

SOLINGAPURAM SAI, K.K.; GAGE, D.; NADER, M.; MACH, R.H.; MINTZ, A. Improved Automated Radiosynthesis of [11C]PBR28. Sci. Pharm. 2015, 83, 413-427.

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