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Sci. Pharm. 2015, 83(2), 221-231; doi:10.3797/scipharm.1411-14 (registering DOI)

Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety

Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Polytechnic National University, Bandera Str. 12, 79013, Lviv, Ukraine.
Laboratoire de Pharmaco-Chimie Radicalaire, Institut de Chimie Radicalaire ICR, Faculté de Pharmacie, Aix-Marseille Univ, CNRS, UMR 7273, Bd J. Moulin 27, 13385, Marseille Cedex 05, France.
Educational and Scientific centre “Institute of Biology”, Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64/13, 01601, Kyiv, Ukraine
Authors to whom correspondence should be addressed.
Received: 26 November 2014 / Accepted: 24 February 2015 / Published: 24 February 2015
Download PDF [296 KB, uploaded 7 September 2016]


Thiosulfonate derivatives based on quinones were synthesized for studying “structure-activity relationship” compounds with an acylated and a free amino-group. Anti-platelet activity of the synthesized compounds was determined and the influence of substituents on the activity of the derivatives was assessed.
Keywords: Thiosulfonate; Quinone; Anti-platelet activity Thiosulfonate; Quinone; Anti-platelet activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

BOLIBRUKH, K.; POLOVKOVYCH, S.; KHOUMERI, O.; HALENOVA, T.; NIKOLAEVA, I.; SAVCHUK, O.; TERME, T.; VANELLE, P.; LUBENETS, V.; NOVIKOV, V. Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety. Sci. Pharm. 2015, 83, 221-231.

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