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Sci. Pharm. 2014, 82(4), 723-734; doi:10.3797/scipharm.1408-05

Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides

Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010, Lviv, Ukraine
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Received: 5 August 2014 / Accepted: 15 September 2014 / Published: 15 September 2014
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Abstract

Novel rel-(5R,6S,7S)-2-oxo-5-phenyl-7-aryl(hetaryl)-3,7-dihydro-2H-thiopyrano [2,3-d]thiazole-6-carboxylic acid amides were synthesized in a hetero-Diels-Alder reaction with a series of cinnamic acid amides. The synthesized compounds were tested for their anticancer activity in vitro in the standard National Cancer Institute 60 cancer cell line assay. Promising compounds 3e, 3g, and 3h with moderate antitumor activity were identified among the synthesized series.
Keywords: hetero-Diels-Alder reaction; Cynnamic acid amides; 5-Ylideneisorhodanines; Thiopyrano[2,3-d][1,3]thiazoles; Anticancer activity hetero-Diels-Alder reaction; Cynnamic acid amides; 5-Ylideneisorhodanines; Thiopyrano[2,3-d][1,3]thiazoles; Anticancer activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

LOZYNSKYI,, A.; ZIMENKOVSKY, B.; LESYK, R. Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides. Sci. Pharm. 2014, 82, 723-734.

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