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Sci. Pharm. 2014, 82(4), 723-734; https://doi.org/10.3797/scipharm.1408-05 (registering DOI)
Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides
Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010, Lviv, Ukraine
Author to whom correspondence should be addressed.
Received: 5 August 2014 / Accepted: 15 September 2014 / Published: 15 September 2014
Abstract Novel rel-(5R,6S,7S)-2-oxo-5-phenyl-7-aryl(hetaryl)-3,7-dihydro-2H-thiopyrano [2,3-d]thiazole-6-carboxylic acid amides were synthesized in a hetero-Diels-Alder reaction with a series of cinnamic acid amides. The synthesized compounds were tested for their anticancer activity in vitro in the standard National Cancer Institute 60 cancer cell line assay. Promising compounds 3e, 3g, and 3h with moderate antitumor activity were identified among the synthesized series.
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LOZYNSKYI,, A.; ZIMENKOVSKY, B.; LESYK, R. Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides. Sci. Pharm. 2014, 82, 723-734.
LOZYNSKYI, A, ZIMENKOVSKY B, LESYK R. Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides. Scientia Pharmaceutica. 2014; 82(4):723-734.
LOZYNSKYI,, Andrii; ZIMENKOVSKY, Borys; LESYK, Roman. 2014. "Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides." Sci. Pharm. 82, no. 4: 723-734.
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