Next Article in Journal
Evaluation of the Anticonvulsant and Anxiolytic Potentials of Methyl Jasmonate in Mice
Previous Article in Journal
Ameliorative Effects of a Polyphenolic Fraction of Cinnamomum zeylanicum L. Bark in Animal Models of Inflammation and Arthritis
Article Menu

Article Versions

Export Article

Open AccessArticle
Sci. Pharm. 2014, 82(3), 631-642; doi:10.3797/scipharm.1406-01

Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays

1
Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
2
Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
3
Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
*
Author to whom correspondence should be addressed.
Received: 2 June 2014 / Accepted: 18 July 2014 / Published: 18 July 2014
Download PDF [233 KB, uploaded 28 September 2016]

Abstract

An insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) and a polymorphism (rs6313) in the serotonin 2A receptor gene (5-HT2A) have previously been linked to smoking behavior. The objective of this study was to determine the possible association of the 5-HTTLPR and 5-HT2A gene polymorphisms with smoking behavior within a population of Malaysian male smokers (n=248) and non-smokers (n=248). The 5-HTTLPR genotypes were determined using the polymerase chain reaction (PCR) and were classified as short (S) alleles or long (L) alleles. The 5HT2A genotypes were determined using PCR–restriction fragment length polymorphisms (PCR-RFLP). No significant differences in the distribution frequencies of the alleles were found between the smokers and the non-smokers for the 5-HTTLPR polymorphism (χ2 = 0.72, P>0.05) or the 5HT2A polymorphism (χ2 = 0.73, P>0.05). This is the first study conducted on Malaysian Malay males regarding the association of 5-HTTLPR and 5HT2A polymorphisms and smoking behavior. However, the genes were not found to be associated with smoking behavior in our population.
Keywords: 5-HTTLPR; 5HT2A; Genetic polymorphism; PCR-RFLP; Malaysian Malays male 5-HTTLPR; 5HT2A; Genetic polymorphism; PCR-RFLP; Malaysian Malays male
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

ROZAK, N.I.A.; AHMAD, I.; GAN, S.H.; BAKAR, R.A. Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays. Sci. Pharm. 2014, 82, 631-642.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top