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Sci. Pharm. 2014, 82(2), 441-448; doi:10.3797/scipharm.1401-14

Formulation and In Vitro Evaluation of Ofloxacin Tablets using Natural Gums as Binders

1
Ashok & Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar-388120, Affiliated to Sardar Patel University, Vallabh Vidyanagar-388120, India
2
Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar-388315, India
3
A. R. College of Pharmacy & G. H. Patel Institute of Pharmacy, Vallabh Vidyanagar-388120, India
4
Chemistry Department, V. P. & R. P. T. P. Science College, Vallabh Vidyanagar-388120, India
*
Author to whom correspondence should be addressed.
Received: 19 January 2014 / Accepted: 10 March 2014 / Published: 10 March 2014
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Abstract

Natural gums are economical, easily available, and useful as tablet binders. In the present investigation, an attempt was made to formulate Ofloxacin tablets using three natural binders, namely Acacia arabica, Hibiscus esculentus, and xanthan gum. Such six batches of Ofloxacin tablets were prepared by using different types and amounts of the natural binders by the wet granulation method. The tablets were analyzed for their hardness, friability, and weight variation, and in vitro release was performed in a phosphate buffer at pH 6.8. The prepared tablets were also evaluated for their various release kinetics and similarity factors f2. The physical properties of the tablets containing the natural binders showed sufficient hardness, desirable disintegration time, and low friability. Their better percentage of drug release was observed as compared to the marketed formulation showing more than 85% drug release within 45 minutes. The in vitro release data was well-fitted into zero-order and the values of release exponent ‘n’ were between 0.303 and 0.514. The high similarity factor f2 of 64.50 was achieved with the best batch in comparison to the marketed tablets. The results obtained indicated that the gum Acacia arabica performed as well as gelatin compared to the other binders for the Ofloxacin tablet formulation.
Keywords: Tablet; Natural binders; Physico-chemical parameters; Release kinetics; Similarity factor Tablet; Natural binders; Physico-chemical parameters; Release kinetics; Similarity factor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

MISTRY, A.K.; NAGDA, C.D.; NAGDA, D.C.; DIXIT, B.C.; DIXIT, R.B. Formulation and In Vitro Evaluation of Ofloxacin Tablets using Natural Gums as Binders. Sci. Pharm. 2014, 82, 441-448.

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