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Sci. Pharm. 2014, 82(2), 411-422; https://doi.org/10.3797/scipharm.1309-17 (registering DOI)
PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies
Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy
School of Advanced Studies ”G. D’Annunzio”, University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo, Chieti, Italy
Author to whom correspondence should be addressed.
Received: 25 September 2013 / Accepted: 6 April 2014 / Published: 6 April 2014
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Abstract A highly water-soluble macromolecular compound of ursolic acid with mono-methoxypoly(ethylene glycol) (mPEG) was prepared. The physicochemical properties and stabilities under different conditions were investigated. By PEG conjugation, greatly increased water solubility was obtained, and the results showed that this conjugate was a potential prodrug for the oral delivery of ursolic acid.
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ZACCHIGNA, M.; CATENI, F.; DRIOLI, S.; PROCIDA, G.; ALTIERI, T. PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies. Sci. Pharm. 2014, 82, 411-422.
ZACCHIGNA M, CATENI F, DRIOLI S, PROCIDA G, ALTIERI T. PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies. Scientia Pharmaceutica. 2014; 82(2):411-422.
ZACCHIGNA, Marina; CATENI, Francesca; DRIOLI, Sara; PROCIDA, Giuseppe; ALTIERI, Tiziano. 2014. "PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies." Sci. Pharm. 82, no. 2: 411-422.
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