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Sci. Pharm. 2013, 81(3), 833-842; doi:10.3797/scipharm.1212-06

Poly-Ingredient Formulation Bresol® Ameliorates Experimental Chronic Obstructive Pulmonary Disease (COPD) in Rats

Department of Pharmacology, R&D Center, The Himalaya Drug Company, Makali, Bangalore, Karnataka, India
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Author to whom correspondence should be addressed.
Received: 6 December 2012 / Accepted: 9 May 2013 / Published: 9 May 2013
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Abstract

In the present study, the protective effect of Bresol® – a polyherbal formulation – was evaluated in an experimental model of cigarette smoke (CS)-induced COPD in rats. Ten minutes daily exposure to CS for 7 weeks caused significant elevation of TNF-α (p<0.01) and total protein (p<0.01) in the bronchoalveolar lavage fluid (BALF) of positive untreated control animals, indicating ongoing inflammatory process in the lungs. Further, histopathological findings have confirmed the presence of pathological lesions in the trachea and lungs. Five weeks of post-treatment with Bresol® (250 and 500 mg/kg,p.o.) showed significant and dose-dependent anti-inflammatory effects against CS-induced lung abnormalities by maintaining the TNF-α and total protein levels within the normal range. Additionally, Bresol®-treated animals showed normal cyto-architecture of the trachea and lungs. In conclusion, Bresol® showed dose-dependent protection against CS-induced lung and tracheal injury in rats, which further indicates, Bresol® is a useful healing agent, may help to decelerate the progression of COPD, and reduce the exacerbations in patients.
Keywords: Bresol®; Cigarette smoke-induced lung injury; Bronchitis; Broncheoalveolar lavage fluid; TNF-α Bresol®; Cigarette smoke-induced lung injury; Bronchitis; Broncheoalveolar lavage fluid; TNF-α
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

RAFIQ, M.; VISWANATHA, G.L.; SURYAKANTH, D.A.; AZEEMUDDIN, M.; JAGADEESH, M.; DHANUSH, K.; PATKI, P.S. Poly-Ingredient Formulation Bresol® Ameliorates Experimental Chronic Obstructive Pulmonary Disease (COPD) in Rats. Sci. Pharm. 2013, 81, 833-842.

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