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Sci. Pharm. 2013, 81(3), 819-832; doi:10.3797/scipharm.1206-02

Cytotoxic Compounds from Brucea mollis

1
Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam
2
Institute of Bioscience and Biotechnology, VAST, 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam
3
College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea
4
Institute of Ecology and Biological Resources, 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam
*
Author to whom correspondence should be addressed.
Received: 3 June 2012 / Accepted: 31 December 2012 / Published: 29 September 2016
Download PDF [213 KB, uploaded 29 September 2016]

Abstract

Ten compounds, including soulameanone (1), isobruceine B (2), 9-methoxy-canthin-6-one (3), bruceolline F (4), niloticine (5), octatriacontan-1-ol (6), bombiprenone (7), α-tocopherol (8), inosine (9), and apigenin 7-O-β-D-glucopyranoside (10), were isolated from the leaves, stems, and roots of Brucea mollis Wall. ex Kurz. Their structures were determined using one- and two-dimensional NMR spectroscopy and mass spectrometry. All compounds were evaluated for their cytotoxic activity against KB (human carcinoma of the mouth), LU-1 (human lung adenocarcinoma), LNCaP (human prostate adeno-carcinoma), and HL-60 (human promyelocytic leukemia) cancer cell lines. Compound 2 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values of 0.39, 0.40, 0.34, and 0.23 μg/mL, respectively. In addition, compounds 3 and 5 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values around 1–4 μg/mL. Compounds 9-methoxycanthin-6-one (3) and niloticine (5) have been discovered for the first time from the Brucea genus.
Keywords: Brucea mollis; Cytotoxicity; Quassinoids; Alkaloids; Triterpenoids Brucea mollis; Cytotoxicity; Quassinoids; Alkaloids; Triterpenoids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

TUNG, M.H.T.; ĐUC, H.V.; HUONG, T.T.; DUONG, N.T.; PHUONG, D.T.; THAO, D.T.; TAI, B.H.; KIM, Y.H.; BACH, T.T.; CUONG, N.M. Cytotoxic Compounds from Brucea mollis. Sci. Pharm. 2013, 81, 819-832.

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