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Sci. Pharm. 2013, 81(3), 807-818; doi:10.3797/scipharm.1306-17

Quantification of Sesquiterpene Lactones in Asteraceae Plant Extracts: Evaluation of their Allergenic Potential

1
Department of Pharmacognosy, University of Vienna, Austria
2
Information Network of Departments of Dermatology, University of Göttingen, Germany
*
Author to whom correspondence should be addressed.
Received: 30 June 2013 / Accepted: 15 August 2013 / Published: 15 August 2013
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Abstract

Sesquiterpene lactones (SLs), mainly those with an activated exocyclic methylene group, are important allergens in Asteraceae (Compositae) plants. As a screening tool, the Compositae mix, consisting of five Asteraceae plant extracts with allergenic potential (feverfew, tansy, arnica, yarrow, and German chamomile) is part of several national patch test baseline series. However, the SL content of the Compositae mix may vary due to the source material. Therefore, a simple spectrophotometric method for the quantitative measure-ment of SLs with the α-methylene-γ-butyrolactone moiety was developed, giving the percentage of allergenic compounds in plant extracts. The method has been validated and five Asteraceae extracts, namely feverfew (Tanacetum parthenium L.), tansy (Tanacetum vulgare L.), arnica (Arnica montana L.), yarrow (Achillea millefolium L.), and German chamomile (Chamomilla recutita L. Rauschert) that have been used in routine patch test screening were evaluated. A good correlation could be found between the results obtained using the proposed spectrophotometric method and the corresponding clinical results. Thus, the introduced method is a valuable tool for evaluating the allergenic potential and for the simple and efficient quality control of plant extracts with allergenic potential.
Keywords: Quantitative determination of sesquiterpene lactones; Allergenic potential of Asteraceae plants; Compositae mix; Allergic contact dermatitis; Alpha-methylene-gamma-lactone Quantitative determination of sesquiterpene lactones; Allergenic potential of Asteraceae plants; Compositae mix; Allergic contact dermatitis; Alpha-methylene-gamma-lactone
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

SALAPOVIC, H.; GEIER, J.; REZNICEK, G. Quantification of Sesquiterpene Lactones in Asteraceae Plant Extracts: Evaluation of their Allergenic Potential. Sci. Pharm. 2013, 81, 807-818.

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