7-Aza-des-A-steroids with Antimicrobial and Cytotoxic Activity
AbstractThis paper describes a convenient approach to the 7-aza-des-A-steroid (6,6a,7,8,9,9a-hexahydro-5H-cyclopenta[h]quinoline) scaffold starting from Grundmann's ketone using two different pyridine annulation protocols. The biological evaluation of the pyridine and pyridinium products revealed that these compounds unexpectedly do not interfere with ergosterol and cholesterol biosynthesis. The pyridinium compound 6 showed significant antimicrobial and cytotoxic activities which are most likely due to its detergent-like structure.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
KROJER, M.; KELLER, M.; BRACHER, F. 7-Aza-des-A-steroids with Antimicrobial and Cytotoxic Activity. Sci. Pharm. 2013, 81, 329-338.
KROJER M, KELLER M, BRACHER F. 7-Aza-des-A-steroids with Antimicrobial and Cytotoxic Activity. Scientia Pharmaceutica. 2013; 81(2):329-338.Chicago/Turabian Style
KROJER, Melanie; KELLER, Marco; BRACHER, Franz. 2013. "7-Aza-des-A-steroids with Antimicrobial and Cytotoxic Activity." Sci. Pharm. 81, no. 2: 329-338.