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Sci. Pharm. 2012, 80(4), 789-824; doi:10.3797/scipharm.1204-27

Biological Activities of 2-Mercaptobenzothiazole Derivatives: A Review

Department of Pharmaceutical Chemistry, J. S. S. College of Pharmacy, Ootacamund-643001, Tamil Nadu, India
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Received: 30 April 2012 / Accepted: 18 June 2012 / Published: 18 June 2012
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Abstract

2-Mercaptobenzothiazoles are an important class of bioactive and industrially important organic compounds. These compounds are reported for their antimicrobial and antifungal activities, and are subsequently highlighted as a potent mechanism-based inhibitor of several enzymes like acyl coenzyme A cholesterol acyltransferase, monoamine oxidase, heat shock protein 90, cathepsin D, and c-Jun N-terminal kinases. These derivatives are also known to possess antitubercular, anti-inflammatory, antitumor, amoebic, antiparkinsonian, anthelmintic, antihypertensive, antihyperlipidemic, antiulcer, chemoprotective, and selective CCR3 receptor antagonist activity. This present review article focuses on the pharmacological profile of 2-mercaptobenzothiazoles with their potentialactivities.
Keywords: 2-Mercaptobenzothiazoles (MBT); 2-Sulfanyl-1,3-benzothiazoles; Antimicrobial activity; Anti-inflammatory activity; Heat shock protein 90; Monoamine oxidase 2-Mercaptobenzothiazoles (MBT); 2-Sulfanyl-1,3-benzothiazoles; Antimicrobial activity; Anti-inflammatory activity; Heat shock protein 90; Monoamine oxidase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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AZAM, M.A.; SURESH, B. Biological Activities of 2-Mercaptobenzothiazole Derivatives: A Review. Sci. Pharm. 2012, 80, 789-824.

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