Next Article in Journal
Synthesis of New N,N'-Bis(5-arylidene-4-oxo-4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological Evaluation
Previous Article in Journal
Development and Characterization of Pharmacokinetic Parameters of Fast-Dissolving Films Containing Levocetirizine
 
 
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Biological Activities of 2-Mercaptobenzothiazole Derivatives: A Review

Department of Pharmaceutical Chemistry, J. S. S. College of Pharmacy, Ootacamund-643001, Tamil Nadu, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2012, 80(4), 789-824; https://doi.org/10.3797/scipharm.1204-27
Submission received: 30 April 2012 / Accepted: 18 June 2012 / Published: 18 June 2012

Abstract

2-Mercaptobenzothiazoles are an important class of bioactive and industrially important organic compounds. These compounds are reported for their antimicrobial and antifungal activities, and are subsequently highlighted as a potent mechanism-based inhibitor of several enzymes like acyl coenzyme A cholesterol acyltransferase, monoamine oxidase, heat shock protein 90, cathepsin D, and c-Jun N-terminal kinases. These derivatives are also known to possess antitubercular, anti-inflammatory, antitumor, amoebic, antiparkinsonian, anthelmintic, antihypertensive, antihyperlipidemic, antiulcer, chemoprotective, and selective CCR3 receptor antagonist activity. This present review article focuses on the pharmacological profile of 2-mercaptobenzothiazoles with their potentialactivities.
Keywords: 2-Mercaptobenzothiazoles (MBT); 2-Sulfanyl-1,3-benzothiazoles; Antimicrobial activity; Anti-inflammatory activity; Heat shock protein 90; Monoamine oxidase 2-Mercaptobenzothiazoles (MBT); 2-Sulfanyl-1,3-benzothiazoles; Antimicrobial activity; Anti-inflammatory activity; Heat shock protein 90; Monoamine oxidase

Share and Cite

MDPI and ACS Style

AZAM, M.A.; SURESH, B. Biological Activities of 2-Mercaptobenzothiazole Derivatives: A Review. Sci. Pharm. 2012, 80, 789-824. https://doi.org/10.3797/scipharm.1204-27

AMA Style

AZAM MA, SURESH B. Biological Activities of 2-Mercaptobenzothiazole Derivatives: A Review. Scientia Pharmaceutica. 2012; 80(4):789-824. https://doi.org/10.3797/scipharm.1204-27

Chicago/Turabian Style

AZAM, Mohammed Afzal, and Bhojraj SURESH. 2012. "Biological Activities of 2-Mercaptobenzothiazole Derivatives: A Review" Scientia Pharmaceutica 80, no. 4: 789-824. https://doi.org/10.3797/scipharm.1204-27

Article Metrics

Back to TopTop