Next Article in Journal
Biological Activities of 2-Mercaptobenzothiazole Derivatives: A Review
Previous Article in Journal
Occlusive and Non-Occlusive Application of Microemulsion for Transdermal Delivery of Progesterone: Mechanistic Studies
Article Menu

Article Versions

Export Article

Open AccessArticle
Sci. Pharm. 2012, 80(3), 779-788; doi:10.3797/scipharm.1205-15

Development and Characterization of Pharmacokinetic Parameters of Fast-Dissolving Films Containing Levocetirizine

1
Indukaka Ipcowala College of Pharmacy, New V V Nagar, Anand, Gujarat – 388121, India
2
College of Pharmacy, V V Nagar, Anand, Gujarat – 388120, India
*
Author to whom correspondence should be addressed.
Received: 31 May 2012 / Accepted: 22 July 2012 / Published: 22 July 2012
Download PDF [131 KB, uploaded 30 September 2016]

Abstract

A fast-dissolving film containing levocetirizine, a non-sedative antihistamine drug, was developed using pullulan, xanthan gum, propylene glycol, and tween 80 as the base materials. The drug content of the prepared films was within an acceptable limit as prescribed by the USP. The film exhibited excellent stability for four months when stored at 40 °C and 75% humidity. In vitro dissolution studies suggested a rapid disintegration, in which most of levocetirizine (93.54 ± 3.9%) dissolved within 90 seconds after insertion into the medium. Subse-quently, Sprague–Dawley rats were used to compare the pharmacokinetic properties of the film preparation administered to the oral cavity, to those with oral administration of the pure drug solution. The pharmacokinetic parameters were similar between the two groups in which AUC0–t (ng h/ml), AUC0–∞ (ng h/ml) Cmax (ng/ml), Tmax (min), Kel (h−1), and t1/2 (h) of the reference were 452.033 ± 43.68, 465.78 ± 48.16, 237.16 ± 19.87, 30, 0.453 ± 0.051, and 1.536 ± 0.118, respectively, for the film formulation 447.233 ± 46.24, 458.22 ± 46.74, 233.32 ± 17.19, 30, 0.464 ± 0.060, and 1.496 ± 0.293, respectively. These results suggest that the present levocetirizine containing fast-dissolving film is likely to become one of the choices to treat different allergic conditions.
Keywords: Fast dissolving film; Levocetirizine; In-vitro dissolution studies; Pharmacokinetics; Drug content Fast dissolving film; Levocetirizine; In-vitro dissolution studies; Pharmacokinetics; Drug content
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

CHOUDHARY, D.R.; PATEL, V.A.; CHHALOTIYA, U.K.; PATEL, H.V.; KUNDAWALA, A.J. Development and Characterization of Pharmacokinetic Parameters of Fast-Dissolving Films Containing Levocetirizine. Sci. Pharm. 2012, 80, 779-788.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top