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Open AccessCommunication
Sci. Pharm. 2012, 80(3), 663-668; doi:10.3797/scipharm.1204-21

Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone

Institut für Pharmazie, Freie Universität Berlin, Königin-Luise-Straße 2+4, D-14195 Berlin, Germany
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Received: 23 April 2012 / Accepted: 31 May 2012 / Published: 31 May 2012
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Abstract

The cytotoxicity of alpha- and beta-asarone was investigated with the BrdU assay in HepG2-cells. Alpha-asarone was found to be more toxic than beta-asarone after 24 hours of treatment. Investigation of the genotoxicity using the micronucleus assay in the HepG2-cell system showed that only after metabolic activation by a liver microsomal preparation, beta-asarone was able to induce micronuclei at concentrations higher than 50 μg/mL.
Keywords: Asarone; HepG2-cells; Cytotoxicity; Genotoxicity; Micronucleus test Asarone; HepG2-cells; Cytotoxicity; Genotoxicity; Micronucleus test
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

UNGER, P.; MELZIG, M.F. Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone. Sci. Pharm. 2012, 80, 663-668.

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