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Sci. Pharm. 2011, 79(4), 937-950; doi:10.3797/scipharm.1106-21

Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus

1
Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan
2
Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan
*
Author to whom correspondence should be addressed.
Received: 25 June 2011 / Accepted: 3 October 2011 / Published: 3 October 2011
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Abstract

Three new quinazolinobenzodiazepine derivatives, novobenzomalvins A (1), B (2), and C (3), have been isolated as fibronectin expression regulators from Aspergillus novofumigatus CBS117520. The structures of 1 to 3 were established by spectroscopic and physicochemical analysis, and chemical investigation including the total synthesis of 1. Treatment with novo-benzomalvins A (1), B (2), C (3), and N-methylnovobenzomalvin A (5) increased the expression of fibronectin in normal human neonatal dermal fibroblast cells.
Keywords: Aspergillus novofumigatus; Novobenzomalvin; Quinazolinobenzodiazepine; Fibronectin expression regulator; Alkaloids; X-ray crystallography Aspergillus novofumigatus; Novobenzomalvin; Quinazolinobenzodiazepine; Fibronectin expression regulator; Alkaloids; X-ray crystallography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

ISHIKAWA, K.; HOSOE, T.; ITABASHI, T.; SATO, F.; WACHI, H.; NAGASE, H.; YAGUCHI, T.; KAWAI, K.-I. Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus. Sci. Pharm. 2011, 79, 937-950.

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