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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015). Articles in this Volume were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2011, 79(4), 937-950; doi:10.3797/scipharm.1106-21 (registering DOI)

Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus

1
Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan
2
Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan
*
Author to whom correspondence should be addressed.
Received: 25 June 2011 / Accepted: 3 October 2011 / Published: 3 October 2011
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Abstract

Three new quinazolinobenzodiazepine derivatives, novobenzomalvins A (1), B (2), and C (3), have been isolated as fibronectin expression regulators from Aspergillus novofumigatus CBS117520. The structures of 1 to 3 were established by spectroscopic and physicochemical analysis, and chemical investigation including the total synthesis of 1. Treatment with novo-benzomalvins A (1), B (2), C (3), and N-methylnovobenzomalvin A (5) increased the expression of fibronectin in normal human neonatal dermal fibroblast cells.
Keywords: Aspergillus novofumigatus; Novobenzomalvin; Quinazolinobenzodiazepine; Fibronectin expression regulator; Alkaloids; X-ray crystallography Aspergillus novofumigatus; Novobenzomalvin; Quinazolinobenzodiazepine; Fibronectin expression regulator; Alkaloids; X-ray crystallography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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ISHIKAWA, K.; HOSOE, T.; ITABASHI, T.; SATO, F.; WACHI, H.; NAGASE, H.; YAGUCHI, T.; KAWAI, K.-I. Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus. Sci. Pharm. 2011, 79, 937-950.

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