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Sci. Pharm. 2011, 79(3), 615-622; doi:10.3797/scipharm.1104-16

In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)

1
School of Biological Sciences, Queen’s University Belfast, BT9 5AG, Northern Ireland, United Kingdom
2
Agri-Food and Biosciences Institute, Newforge Lane, BT9 5PX, Belfast, Northern Ireland, United Kingdom
3
School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland, United Kingdom
*
Author to whom correspondence should be addressed.
Received: 20 April 2011 / Accepted: 9 June 2011 / Published: 9 June 2011
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Abstract

Glucagon-like peptide-1 (GLP-1) is an intestinal hormone with well-established glucose-lowering activity. The in vitro and in vivo actions of natural putative secretagogues of GLP-1 were investigated. The acute GLP-1 releasing activity of olive leaf extract (OLE), glutamine (GLN), alpha casein (ACAS), beta casein (BCAS) and chlorogenic acid (CGA) were assessed in STC-1 cells and C57BL/6 mice. All compounds except ACAS significantly increased acute in vitro GLP-1 secretion (66-386%; P<0.05–0.001). Oral gavage of OLE and GLN modestly increased plasma GLP-1 concentrations (48% and 41%, respectively), but did not lower glycaemic excursions. OLE and GLN are potent stimulators of GLP-1 secretion both in vitro and in vivo and chronic studies should assess their suitability as nutritional therapies for type 2 diabetes.
Keywords: Diabetes; Glucose; Hormone; Secretion; Olive leaf extract; Glutamine; Casein; Chlorogenic acid Diabetes; Glucose; Hormone; Secretion; Olive leaf extract; Glutamine; Casein; Chlorogenic acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

RAFFERTY, E.P.; WYLIE, A.R.; ELLIOTT, C.T.; CHEVALLIER, O.P.; GRIEVE, D.J.; GREEN, B.D. In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1). Sci. Pharm. 2011, 79, 615-622.

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