Next Article in Journal
Validation of a Stability-Indicating Hydrophilic Interaction Liquid Chromatographic Method for the Quantitative Determination of Vitamin K3 (Menadione Sodium Bisulfite) in Injectable Solution Formulation
Previous Article in Journal
Pioglitazone and Endothelial Dysfunction: Pleiotropic Effects and Possible Therapeutic Implications
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 79
Issue 3
10.3797/scipharm.1101-19
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurities in Verapamil Hydrochloride

by
Viswanathan SRINIVASAN
1,2,*,
Hariharan SIVARAMAKRISHNAN
3 and
Balakrishnan KARTHIKEYAN
2
1
Analytical Development Laboratory, Piramal Healthcare Ltd, Ennore, Chennai 600 057, India
2
Department of Chemistry, Annamalai University, Annamalainagar 608 002, India
3
Research and Development Laboratory, Piramal Healthcare Ltd, Ennore, Chennai 600 057, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2011, 79(3), 555-568; https://doi.org/10.3797/scipharm.1101-19
Submission received: 26 January 2011 / Accepted: 8 May 2011 / Published: 8 May 2011
Versions Notes

Abstract

Two unknown impurities were detected in verapamil hydrochloride bulk drug using isocratic reversed-phase high performance liquid chromatography (HPLC). These impurities were isolated by preparative HPLC. Spectral data for the isolated impurities were collected. Based on the spectral data derived from two-dimensional nuclear magnetic resonance (2D-NMR) spectroscopy and mass spectrometry (MS), impurity-1 and impurity-2 were characterized as 2-(3,4-dimethoxyphenyl)-3-methylbut-2-enenitrile and 2-(3,4-dimethoxyphenyl)-2-isopropyl-3-methylbutanenitrile, respectively.
Keywords: Verapamil hydrochloride; NMR; HPLC; MS; Impurity Analysis Verapamil hydrochloride; NMR; HPLC; MS; Impurity Analysis

Share and Cite

MDPI and ACS Style

SRINIVASAN, V.; SIVARAMAKRISHNAN, H.; KARTHIKEYAN, B. Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurities in Verapamil Hydrochloride. Sci. Pharm. 2011, 79, 555-568. https://doi.org/10.3797/scipharm.1101-19

AMA Style

SRINIVASAN V, SIVARAMAKRISHNAN H, KARTHIKEYAN B. Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurities in Verapamil Hydrochloride. Scientia Pharmaceutica. 2011; 79(3):555-568. https://doi.org/10.3797/scipharm.1101-19

Chicago/Turabian Style

SRINIVASAN, Viswanathan, Hariharan SIVARAMAKRISHNAN, and Balakrishnan KARTHIKEYAN. 2011. "Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurities in Verapamil Hydrochloride" Scientia Pharmaceutica 79, no. 3: 555-568. https://doi.org/10.3797/scipharm.1101-19

Article Metrics

Back to TopTop