Next Article in Journal
Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents
Previous Article in Journal
Nachruf für Prof. Dr. Matthias Pailer
Article Menu

Article Versions

Export Article

Open AccessReview
Sci. Pharm. 2011, 79(3), 389-428; doi:10.3797/scipharm.1012-08

Neglected Disease – African Sleeping Sickness: Recent Synthetic and Modeling Advances

1
Banasthali University, Distt-Tonk, 304022, Rajasthan, India
2
LLRM medical college, Meerut (U.P.), India
*
Author to whom correspondence should be addressed.
Received: 9 December 2010 / Accepted: 10 May 2011 / Published: 10 May 2011
Download PDF [350 KB, uploaded 28 September 2016]

Abstract

Human African Trypanosomiasis (HAT) also called sleeping sickness is caused by subspecies of the parasitic hemoflagellate Trypanosoma brucei that mostly occurs in sub-Saharan Africa. The current chemotherapy of the human trypanosomiases relies on only six drugs, five of which have been developed more than 30 years ago, have undesirable toxic side effects and most of them show drug-resistance. Though development of new anti-trypanosomal drugs seems to be a priority area research in this area has lagged far behind. The given review mainly focus upon the recent synthetic and computer based approaches made by various research groups for the development of newer anti-trypanosomal analogues which may have improved efficacy and oral bioavailability than the present ones. The given paper also attempts to investigate the relationship between the various physiochemical parameters and anti-trypanosomal activity that may be helpful in development of potent anti-trypanosomal agents against sleeping sickness.
Keywords: Human African Trypanosomiasis (HAT); Computer assisted drug design (CADD); Central nervous system (CNS); Structure-activity relationship (SAR); Trypanothione reductase (TR) Human African Trypanosomiasis (HAT); Computer assisted drug design (CADD); Central nervous system (CNS); Structure-activity relationship (SAR); Trypanothione reductase (TR)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

PALIWAL, S.K.; VERMA, A.N.; PALIWAL, S. Neglected Disease – African Sleeping Sickness: Recent Synthetic and Modeling Advances. Sci. Pharm. 2011, 79, 389-428.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top