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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2011, 79(3), 389-428; https://doi.org/10.3797/scipharm.1012-08 (registering DOI)

Neglected Disease – African Sleeping Sickness: Recent Synthetic and Modeling Advances

1
Banasthali University, Distt-Tonk, 304022, Rajasthan, India
2
LLRM medical college, Meerut (U.P.), India
*
Author to whom correspondence should be addressed.
Received: 9 December 2010 / Accepted: 10 May 2011 / Published: 10 May 2011
PDF [350 KB, uploaded 28 September 2016]

Abstract

Human African Trypanosomiasis (HAT) also called sleeping sickness is caused by subspecies of the parasitic hemoflagellate Trypanosoma brucei that mostly occurs in sub-Saharan Africa. The current chemotherapy of the human trypanosomiases relies on only six drugs, five of which have been developed more than 30 years ago, have undesirable toxic side effects and most of them show drug-resistance. Though development of new anti-trypanosomal drugs seems to be a priority area research in this area has lagged far behind. The given review mainly focus upon the recent synthetic and computer based approaches made by various research groups for the development of newer anti-trypanosomal analogues which may have improved efficacy and oral bioavailability than the present ones. The given paper also attempts to investigate the relationship between the various physiochemical parameters and anti-trypanosomal activity that may be helpful in development of potent anti-trypanosomal agents against sleeping sickness.
Keywords: Human African Trypanosomiasis (HAT); Computer assisted drug design (CADD); Central nervous system (CNS); Structure-activity relationship (SAR); Trypanothione reductase (TR) Human African Trypanosomiasis (HAT); Computer assisted drug design (CADD); Central nervous system (CNS); Structure-activity relationship (SAR); Trypanothione reductase (TR)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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PALIWAL, S.K.; VERMA, A.N.; PALIWAL, S. Neglected Disease – African Sleeping Sickness: Recent Synthetic and Modeling Advances. Sci. Pharm. 2011, 79, 389-428.

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