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Sci. Pharm. 2011, 79(2), 375-386; doi:10.3797/scipharm.1101-22

Physicochemical Characterization and Dissolution Properties of Meloxicam-Gelucire 50/13 Binary Systems

1
Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. BOX 2457, Riyadh 11451, Saudi Arabia
2
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University 71526, Assiut, Egypt
Received: 29 January 2011 / Accepted: 6 April 2011 / Published: 10 April 2011
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Abstract

A solid dispersion of Meloxicam (MX), a poorly soluble, non steroidal antiinflammatory drug, and Gelucire 50/13 was prepared by spray drying. Spherical microparticles were yielded with smooth surfaces as observed by scanning electron microscopy. According to differential scanning calorimetry and powder X-ray diffractometry analysis, MX was transformed from the crystalline state to the amorphous state as confirmed by the disappearance of its melting peak and the crystalline peaks. The dissolution tests at pH 7.4 revealed that the dissolution rate of encapsulated MX was 2.5-fold higher than that of the corresponding physical mixture and fourfold higher than the drug alone, respectively. The microparticles prepared at a ratio of 1:4 (drug/Gelucire) exhibited a 4-fold higher anti-inflammatory activity on the paw edema of rats in comparison to the drug alone. All in all, this work reveals that spray drying is a suitable technique for preparation of solid dispersions with improved biopharmaceutical and pharmacological characteristics of MX.
Keywords: Solid dispersion; Meloxicam; Spray drying; Dissolution; Anti-inflammatory activity; Powder X-ray diffractometry analysis; Scanning electron microscopy Solid dispersion; Meloxicam; Spray drying; Dissolution; Anti-inflammatory activity; Powder X-ray diffractometry analysis; Scanning electron microscopy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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EL-BADRY, M. Physicochemical Characterization and Dissolution Properties of Meloxicam-Gelucire 50/13 Binary Systems. Sci. Pharm. 2011, 79, 375-386.

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