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Sci. Pharm. 2011, 79(2), 265-276; doi:10.3797/scipharm.1011-08

Preparation and Quality Control of the [153Sm]-Samarium Maltolate Complex as a Lanthanide Mobilization Product in Rats

1
Inorganic Chemistry Department, Faculty of Sciences, Tehran University, Tehran, Iran
2
Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
*
Author to whom correspondence should be addressed.
Received: 23 November 2010 / Accepted: 24 February 2011 / Published: 24 February 2011
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Abstract

Development of lanthanide detoxification agents and protocols is of great importance in management of overdoses. Due to safety of maltol as a detoxifying agent in metal overloads, it can be used as a lanthanide detoxifying agent. In order to demonstrate the biodistribution of final complex, [153Sm]- samarium maltolate was prepared using Sm-153 chloride (radiochemical purity >99.9%; ITLC and specific activity). The stability of the labeled compound was determined in the final solution up to 24h as well as the partition coefficient. Biodistribution studies of Sm-153 chloride, [153Sm]-samarium maltolate were carried out in wild-type rats comparing the critical organ uptakes. Comparative study for Sm3+ cation and the labeled compound was conducted up to 48 h, demonstrating a more rapid wash out for the labeled compound. The effective and biological half lives of 2.3 h and 2.46h were calculated for the complex. The data suggest the detoxification property of maltol formulation for lanthanide overdoses.
Keywords: Detoxification; Maltolate; Sm-153; Biodistribution; Radiolabeling Detoxification; Maltolate; Sm-153; Biodistribution; Radiolabeling
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

NASERI, Z.; HAKIMI, A.; JALILIAN, A.R.; NEMATI KHARAT, A.; BAHRAMI-SAMANI, A.; GHANNADI-MARAGHEH, M. Preparation and Quality Control of the [153Sm]-Samarium Maltolate Complex as a Lanthanide Mobilization Product in Rats. Sci. Pharm. 2011, 79, 265-276.

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