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Sci. Pharm. 2011, 79(1), 21-30; doi:10.3797/scipharm.1011-10

New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities

Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5–13, D-81377 Munich, Germany
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Received: 30 November 2010 / Accepted: 17 December 2010 / Published: 18 December 2010
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Abstract

New isocoumarins were prepared in an efficient way from 2-iodobenzoic acid derivatives and hept-1-yne in a Sonogashira reaction, followed by spontaneous cyclization. Catalytic hydrogenation gave the corresponding dihydroisocoumarins. A 4-chloroisocoumarin was prepared on an alternative pathway. Some of the new compounds showed moderate cytotoxic activities against a human leukemia cell line (HL 60).
Keywords: Isocoumarins; Dihydroisocoumarins; Sonogashira reaction; Cyclization; Cytotoxicity Isocoumarins; Dihydroisocoumarins; Sonogashira reaction; Cyclization; Cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hampl, V.; Wetzel, I.; Bracher, F.; KRAUSS, J. New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities. Sci. Pharm. 2011, 79, 21-30.

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