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Sci. Pharm. 2010, 78(4), 941-958; doi:10.3797/scipharm.1004-24

Sodium Alginate Based Mucoadhesive System for Gatifloxacin and Its In Vitro Antibacterial Activity

1
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh – 221 005, India
2
Department of Microbiology, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh – 221 005, India
*
Author to whom correspondence should be addressed.
Received: 30 April 2010 / Accepted: 6 September 2010 / Published: 26 September 2010
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Abstract

The objective of this study was to formulate sodium alginate based ophthalmic mucoadhesive system of gatifloxacin and its in vitro antibacterial potential on pathogenic microorganisms, Staphylococcus aureus and Escherichia coli. Sodium carboxymethylcellulose (NaCMC) was added to the formulations to enhance the gel bioadhesion properties. The prepared formulations were evaluated for their in vitro drug release, gelation behaviour, rheological behavior, and mucoadhesion force. All formulations in non-physiological and physiological condition showed pseudo plastic behavior. Increase in the concentration of sodium alginate and sodium CMC enhanced the mucoadhesive force significantly. In vitro release of gatifloxacin from the system in simulated tear fluid (STF, pH – 7.4), was influenced significantly by the properties and concentration of sodium alginate, NaCMC. Significant reduction in total bacterial count was observed between control and treatment groups with both the test organisms.
Keywords: Gatifloxacin; Mucoadhesive; Mucin; In vitro release; In vitro antibacterial study; Rheology Gatifloxacin; Mucoadhesive; Mucin; In vitro release; In vitro antibacterial study; Rheology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

KESAVAN, K.; NATH, G.; PANDIT, J.K. Sodium Alginate Based Mucoadhesive System for Gatifloxacin and Its In Vitro Antibacterial Activity. Sci. Pharm. 2010, 78, 941-958.

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