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Sci. Pharm. 2010, 78(4), 753-766; doi:10.3797/scipharm.1009-15

New 4-Thiazolidinones of Nicotinic Acid with 2-Amino-6-methylbenzothiazole and their Biological Activity

Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, Gujarat, India
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Received: 26 September 2010 / Accepted: 24 October 2010 / Published: 24 October 2010
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Abstract

The title compounds 6a–j, 2-[(6-methyl-1,3-benzothiazol-2-yl)amino]-N- [2-(substituted phenyl/furan-2-yl)-4-oxo-1,3-thiazolidin-3-yl]nicotinamides, were prepared from 2-chloropyridine-3-carboxylic acid (1) and 2-amino-6-methylbenzothiazole (2) by known methods. All the compounds have been established by IR, 1H NMR, 13C NMR and elemental analyses. The in vitro antimicrobial screening of the compounds were carried out against two Gram positive (S. aureus, S. pyogenes), two Gram negative (E. coli, P. aeruginosa) bacteria and three fungal species (C. albicans, A. niger, A. clavatus) using the broth microdilution method. Some of the compounds are comparable with standard drugs.
Keywords: Antimicrobial activity; Schiff bases; 4-Thiazolidinones; Nicotinic acid Antimicrobial activity; Schiff bases; 4-Thiazolidinones; Nicotinic acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

PATEL, N.B.; SHAIKH, F.M. New 4-Thiazolidinones of Nicotinic Acid with 2-Amino-6-methylbenzothiazole and their Biological Activity. Sci. Pharm. 2010, 78, 753-766.

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