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Sci. Pharm. 2010, 78(3), 696; https://doi.org/10.3797/scipharm.cespt.8.PPAT07 (registering DOI)
Experimental and Mathematical Analysis of Hepatic Uptake
School of Engineering, University of Warwick, Coventry, CV4 7AL, United Kingdom
Departments of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
DMPK Department, Astrazeneca, Alderley Park, Macclesfield, United Kingdom
Author to whom correspondence should be addressed.
Received: 12 July 2010 / Accepted: 12 July 2010 / Published: 12 July 2010
Abstract Introduction: To investigate the nonlinear kinetics of in vitro hepatic uptake the OATP substrate, Pitivastatin, was used as a probe. Experiments were conducted using freshly isolated rat hepatocytes, utilising the ‘oil spin’ methodology described by Hassen et al . [...]
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GRANDJEAN, T.; LENCH, A.; YATES, J.W.T.; CHAPPELL, M.J.; O‘DONNELL, C.J. Experimental and Mathematical Analysis of Hepatic Uptake. Sci. Pharm. 2010, 78, 696.
GRANDJEAN T, LENCH A, YATES JWT, CHAPPELL MJ, O‘DONNELL CJ. Experimental and Mathematical Analysis of Hepatic Uptake. Scientia Pharmaceutica. 2010; 78(3):696.
GRANDJEAN, T.; LENCH, A.; YATES, J. W. T.; CHAPPELL, M. J.; O‘DONNELL, C. J. 2010. "Experimental and Mathematical Analysis of Hepatic Uptake." Sci. Pharm. 78, no. 3: 696.
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