Next Article in Journal
Chemical Structure Role of Cell-Membrane Hydrocarbon Chain in Interactions with Antihypertensive Drugs (SARTANs)
Previous Article in Journal
Kinetic Pathway Analysis of Aggregation of Therapeutic Proteins
Article Menu

Article Versions

Export Article

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessConference Report
Sci. Pharm. 2010, 78(3), 696; https://doi.org/10.3797/scipharm.cespt.8.PPAT07 (registering DOI)

Experimental and Mathematical Analysis of Hepatic Uptake

1
School of Engineering, University of Warwick, Coventry, CV4 7AL, United Kingdom
2
Departments of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
3
DMPK Department, Astrazeneca, Alderley Park, Macclesfield, United Kingdom
*
Author to whom correspondence should be addressed.
Received: 12 July 2010 / Accepted: 12 July 2010 / Published: 12 July 2010
Download PDF [130 KB, uploaded 11 October 2016]

Abstract

Introduction: To investigate the nonlinear kinetics of in vitro hepatic uptake the OATP substrate, Pitivastatin, was used as a probe. Experiments were conducted using freshly isolated rat hepatocytes, utilising the ‘oil spin’ methodology described by Hassen et al [1]. [...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

GRANDJEAN, T.; LENCH, A.; YATES, J.W.T.; CHAPPELL, M.J.; O‘DONNELL, C.J. Experimental and Mathematical Analysis of Hepatic Uptake. Sci. Pharm. 2010, 78, 696.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top