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Sci. Pharm. 2010, 78(3), 696; doi:10.3797/scipharm.cespt.8.PPAT07

Experimental and Mathematical Analysis of Hepatic Uptake

1
School of Engineering, University of Warwick, Coventry, CV4 7AL, United Kingdom
2
Departments of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
3
DMPK Department, Astrazeneca, Alderley Park, Macclesfield, United Kingdom
*
Author to whom correspondence should be addressed.
Received: 12 July 2010 / Accepted: 12 July 2010 / Published: 12 July 2010
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Abstract

Introduction: To investigate the nonlinear kinetics of in vitro hepatic uptake the OATP substrate, Pitivastatin, was used as a probe. Experiments were conducted using freshly isolated rat hepatocytes, utilising the ‘oil spin’ methodology described by Hassen et al [1]. [...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

GRANDJEAN, T.; LENCH, A.; YATES, J.W.T.; CHAPPELL, M.J.; O‘DONNELL, C.J. Experimental and Mathematical Analysis of Hepatic Uptake. Sci. Pharm. 2010, 78, 696.

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