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Sci. Pharm. 2010, 78(3), 696; doi:10.3797/scipharm.cespt.8.PPAT07 (registering DOI)

Experimental and Mathematical Analysis of Hepatic Uptake

School of Engineering, University of Warwick, Coventry, CV4 7AL, United Kingdom
Departments of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
DMPK Department, Astrazeneca, Alderley Park, Macclesfield, United Kingdom
Author to whom correspondence should be addressed.
Received: 12 July 2010 / Accepted: 12 July 2010 / Published: 12 July 2010
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Introduction: To investigate the nonlinear kinetics of in vitro hepatic uptake the OATP substrate, Pitivastatin, was used as a probe. Experiments were conducted using freshly isolated rat hepatocytes, utilising the ‘oil spin’ methodology described by Hassen et al [1]. [...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

GRANDJEAN, T.; LENCH, A.; YATES, J.W.T.; CHAPPELL, M.J.; O‘DONNELL, C.J. Experimental and Mathematical Analysis of Hepatic Uptake. Sci. Pharm. 2010, 78, 696.

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