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Sci. Pharm. 2010, 78(3), 686; doi:10.3797/scipharm.cespt.8.PNM16

Protamine Based siRNA-Nanoparticles: Particle Composition Dependant Influences on RNA Interference Efficiency

1
Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens-University Graz, Austria
2
Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria
*
Author to whom correspondence should be addressed.
Received: 12 July 2010 / Accepted: 12 July 2010 / Published: 12 July 2010
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Abstract

The major limitations for the use of small interfering RNA (siRNA) in vivo and in vitro are the relatively high molecular weight, the negative charge, and the susceptibility to nuclease degradation [1]. [...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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REISCHL, D.; JANTSCHER-KRENN, E.; BERNHART, E.; SATTLER, W.; ZIMMER, A. Protamine Based siRNA-Nanoparticles: Particle Composition Dependant Influences on RNA Interference Efficiency. Sci. Pharm. 2010, 78, 686.

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