Next Article in Journal
Contribution of Thromboxane A2 in Rat Common Carotid Artery Response to Serotonin
Previous Article in Journal
Method Development and Validation of Montelukast in Human Plasma by HPLC Coupled with ESI-MS/MS: Application to a Bioequivalence Study
Article Menu

Article Versions

Export Article

Open AccessArticle
Sci. Pharm. 2010, 78(3), 423-434; doi:10.3797/scipharm.1004-21

Production, Quality Control and Pharmacokinetic Studies of 166Ho-EDTMP for Therapeutic Applications

1
Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Postal code: 14155-1339, Iran
2
Faculty of Nuclear Engineering and Physics, Amir Kabir University, Tehran, Iran
*
Author to whom correspondence should be addressed.
Received: 26 April 2010 / Accepted: 9 June 2010 / Published: 9 June 2010
Download PDF [477 KB, uploaded 29 September 2016]

Abstract

166Ho-EDTMP is a major therapeutic agent which is widely used in bone palliation therapy. In this study, a 166Ho-EDTMP complex was prepared successfully using an in-house synthesized EDTMP ligand and 166HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 ncm−2s−1) of natural Ho(NO3)3 samples (specific activity = 3–5 GBq/mg), dissolved in acidic media. The radiochemical purity of 166Ho-EDTMP was checked by ITLC (>99%) and stability studies in presence of human serum and final preparation were performed. The biodistribution of 166Ho-EDTMP and 166HoCl3 in wild-type rats was checked by scarification. SPECT imaging of 166Ho-EDTMP was also performed in wild-type rats. A comparative accumulation study for 166Ho-EDTMP and 166HoCl3 was performed for vital organs up to 48h. Significant bone accumulation (>70%) of the tracer in 48h was observed.
Keywords: Holmium-166; EDTMP; Radiopharmaceutical therapy; Biokinetic Holmium-166; EDTMP; Radiopharmaceutical therapy; Biokinetic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

BAHRAMI-SAMANI, A.; BAGHERI, R.; JALILIAN, A.R.; SHIRVANI-ARAni, S.; GHANNADI-MARAGHEH, M.; SHAMSAEE, M. Production, Quality Control and Pharmacokinetic Studies of 166Ho-EDTMP for Therapeutic Applications. Sci. Pharm. 2010, 78, 423-434.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top