Production, Quality Control and Pharmacokinetic Studies of 166Ho-EDTMP for Therapeutic Applications
Abstract166Ho-EDTMP is a major therapeutic agent which is widely used in bone palliation therapy. In this study, a 166Ho-EDTMP complex was prepared successfully using an in-house synthesized EDTMP ligand and 166HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 ncm−2s−1) of natural Ho(NO3)3 samples (specific activity = 3–5 GBq/mg), dissolved in acidic media. The radiochemical purity of 166Ho-EDTMP was checked by ITLC (>99%) and stability studies in presence of human serum and final preparation were performed. The biodistribution of 166Ho-EDTMP and 166HoCl3 in wild-type rats was checked by scarification. SPECT imaging of 166Ho-EDTMP was also performed in wild-type rats. A comparative accumulation study for 166Ho-EDTMP and 166HoCl3 was performed for vital organs up to 48h. Significant bone accumulation (>70%) of the tracer in 48h was observed.
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BAHRAMI-SAMANI, A.; BAGHERI, R.; JALILIAN, A.R.; SHIRVANI-ARAni, S.; GHANNADI-MARAGHEH, M.; SHAMSAEE, M. Production, Quality Control and Pharmacokinetic Studies of 166Ho-EDTMP for Therapeutic Applications. Sci. Pharm. 2010, 78, 423-434.
BAHRAMI-SAMANI A, BAGHERI R, JALILIAN AR, SHIRVANI-ARAni S, GHANNADI-MARAGHEH M, SHAMSAEE M. Production, Quality Control and Pharmacokinetic Studies of 166Ho-EDTMP for Therapeutic Applications. Scientia Pharmaceutica. 2010; 78(3):423-434.Chicago/Turabian Style
BAHRAMI-SAMANI, Ali; BAGHERI, Reza; JALILIAN, Amir R.; SHIRVANI-ARAni, Simindokht; GHANNADI-MARAGHEH, Mohammad; SHAMSAEE, Mojtaba. 2010. "Production, Quality Control and Pharmacokinetic Studies of 166Ho-EDTMP for Therapeutic Applications." Sci. Pharm. 78, no. 3: 423-434.