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Sci. Pharm. 2010, 78(2), 171-194; https://doi.org/10.3797/scipharm.0912-16 (registering DOI)
Synthesis and Antimicrobial Activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones
Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, Gujarat, India
Author to whom correspondence should be addressed.
Received: 17 December 2009 / Accepted: 26 April 2010 / Published: 26 April 2010
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Abstract In attempt to find new pharmacologically active molecules, we report here the synthesis and in vitro antimicrobial activity of various 3-(1,3,4-oxadiazol-2-yl)- quinazolin-4(3H)-ones. The antimicrobial activity of title compounds were examined against two gram positive bacteria (S. aureus, S. pyogenes), two gram negative bacteria (E. coli, P. aeruginosa) and three fungi (C. albicans, A. niger, A. clavatus) using the broth microdilution method. Some derivatives bearing a bromo or iodo group exhibited very good antimicrobial activity.
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PATEL, N.B.; PATEL, J.C. Synthesis and Antimicrobial Activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones. Sci. Pharm. 2010, 78, 171-194.
PATEL NB, PATEL JC. Synthesis and Antimicrobial Activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones. Scientia Pharmaceutica. 2010; 78(2):171-194.
PATEL, Navin B.; PATEL, Jaymin C. 2010. "Synthesis and Antimicrobial Activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones." Sci. Pharm. 78, no. 2: 171-194.
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