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Sci. Pharm. 2009, 77(Posters (PO)), 226; doi:10.3797/scipharm.oephg.21.PO-27 (registering DOI)

Ligand Determinants of Drug Trapping in hERG Potassium Channels

1
Department of Pharmacology and Toxicology, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
2
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Excerpt

Inhibition of hERG channels prolongs the ventricular action potential and correspondingly the QT-interval with the risk of torsade de pointes arrhythmias which may result in sudden cardiac death.[...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

WINDISCH, A.; SCHIESARO, A.; THAI, K.-M.; TIMIN, E.; HOHAUS, A.; ECKER, G.F.; HERING, S. Ligand Determinants of Drug Trapping in hERG Potassium Channels. Sci. Pharm. 2009, 77, 226.

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