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Sci. Pharm. 2009, 77(Posters (PO)), 220; doi:10.3797/scipharm.oephg.21.PO-21 (registering DOI)

Transport of NSAIDs across the Blood-Brain Barrier in vitro

1
Department of Medicinal Chemistry, University of Vienna, Pharmacy Center, Althanstraße 14, 1090 Vienna, Austria
2
PharmaCon GmbH, Riglergasse 4/5, 1180, Vienna, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Abstract

The migration of substances between blood circulation and central nervous system (CNS) is regulated by the blood-brain barrier (BBB). Small lipophilic molecules such as carbon dioxide, oxygen or ethanol can pass the BBB by passive, transcellular diffusion, while the paracellular transport of hydrophilic substances is restricted by intercellular tight-junctions. Due to accessory transport systems the BBB is able to regulate specifically the permeation of substances (e.g. nutrients) [1].
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

NOVAKOVA, I.; NEUHAUS, W.; SONNENBERG, M.; NOE, C.R. Transport of NSAIDs across the Blood-Brain Barrier in vitro. Sci. Pharm. 2009, 77, 220.

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