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Sci. Pharm. 2009, 77(Short Lectures (SL)), 194; https://doi.org/10.3797/scipharm.oephg.21.SL-27 (registering DOI)
Reverse Chemical Proteomics in Drug Discovery
Department of Chemistry & Biomolecular Sciences, Macquarie University, Sydney, NSW, 2109 Australia
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Abstract With advances in separation technology and structure elucidation, the main bottleneck limiting drug development from natural products is the identification of their cellular targets. Although effective therapeutic agents can be developed and successfully administered without knowledge of the underlying mechanism of action, elucidation of drug target proteins is essential in the design of new compounds with improved safety and efficacy .[...]
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GOTSBACHER, M.; KARUSO, P. Reverse Chemical Proteomics in Drug Discovery. Sci. Pharm. 2009, 77, 194.
GOTSBACHER M, KARUSO P. Reverse Chemical Proteomics in Drug Discovery. Scientia Pharmaceutica. 2009; 77(Short Lectures (SL)):194.
GOTSBACHER, M.; KARUSO, P. 2009. "Reverse Chemical Proteomics in Drug Discovery." Sci. Pharm. 77, Short Lectures (SL): 194.
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